中国医科大学学报2024，Vol.53Issue(3)：257-262,6.DOI:10.12007/j.issn.0258-4646.2024.03.012
滋阴清肾饮治疗阴虚内热证狼疮肾炎的临床疗效观察
Clinical effect of Ziyin Qingshenyin on lupus nephritis with Yin deficiency and internal heat syndrome
摘要
Abstract
Objective To observe the clinical effect of Ziyin Qingshenyin on lupus nephritis(LN)with Yin deficiency and internal heat syndrome.Methods Sixty patients diagnosed with LN were selected from June 2020 to May 2022 from our hospital as research partici-pants and randomly divided into control group(n=30)and combination group(n=30).The control and combination groups were adminis-tered conventional Western medicine and conventional Western medicine with Ziyin Qingshenyin,respectively.Clinical efficacy,traditional Chinese medicine(TCM)syndrome score and efficacy,renal function index[serum albumin(ALB),serum creatinine(sCr),hemoglobin(Hb),blood urea nitrogen(BUN),and 24 h urinary protein quantitation(24 h Upro)],immunological indicators[complement C3,com-plement C4,immunoglobulin(Ig)M,IgG,and IgA],inflammatoryindicators[C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)],disease activity score of systemic lupus erythematosus(SLEDAI),and safety were determined.Results The total effective rate(86.67%,83.33%)of the combination group was higher than that of the control group(63.33%,60.00%)(P＜0.05).Following treatment,the five syndrome scores of heat,sore throat,night sweats,and macula in combination group were lower than those in the control group(P＜0.05).After treatment,24 h Upro,BUN,sCr,IgM,IgG,IgA,CRP,ESR,and SLEDAI scores in the combination group were lower than those in control group,while ALB,Hb,complement C3,and complement C4 were higher than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The Ziyin Qingshen-yin treatment has notable effects on LN with Yin deficiency and internal heat syndrome,which can improve renal function and immunolog-ical indexes,reduce inflammatory factors,and contribute to disease control.关键词
滋阴清肾饮/治疗/阴虚内热证/狼疮肾炎Key words
Ziyin Qingshenyin/treatment/Yin deficiency and internal heat syndrome/lupus nephritis分类
医药卫生引用本文复制引用
陈丹,何诚明,张海霞..滋阴清肾饮治疗阴虚内热证狼疮肾炎的临床疗效观察[J].中国医科大学学报,2024,53(3):257-262,6.基金项目
江西省中医药管理局科技计划(2022B124) （2022B124）
