中国医科大学学报2024，Vol.53Issue(3)：276-281,6.DOI:10.12007/j.issn.0258-4646.2024.03.016
铁死亡及其抑制剂在中枢神经系统疾病中的研究进展
Progress in ferroptosis and its inhibitors in central nervous system diseases
摘要
Abstract
The etiology of central nervous system(CNS)diseases is complex and mostly unknown,and patients are often left with sequelae and poor prognosis.Recently,ferroptosis has emerged as a unique oxidative stress-induced cell death pathway and is important in various CNS diseases.It is an important mode of neuronal cell death.This article summarizes the molecular mechanism of ferroptosis,research progress of ferroptosis in CNS diseases,and application of ferroptosis inhibitors in CNS diseases to provide new targets and clini-cal references for CNS disease treatment.关键词
中枢神经系统疾病/铁死亡/铁/脂质过氧化/抑制剂Key words
central nervous system disease/ferroptosis/iron/lipid peroxidation/inhibitor分类
医药卫生引用本文复制引用
王雅诗,华祚玉,张立新..铁死亡及其抑制剂在中枢神经系统疾病中的研究进展[J].中国医科大学学报,2024,53(3):276-281,6.基金项目
国家自然科学基金(81101462) （81101462）
国家科技部重点研发计划(2020YFC2005703,2020YFC2007604) （2020YFC2005703,2020YFC2007604）
辽宁省自然科学基金(2019-KF-01-06) （2019-KF-01-06）
