中国医学前沿杂志（电子版）2024，Vol.16Issue(2)：78-87,10.DOI:10.12037/YXQY.2024.02-12
线粒体质量控制与肿瘤研究进展
Research progress on the tumor and mitochondrial quality control
吴昀紫 1郗博洲 2马亮亮 3杨鑫 1解亦斌1
作者信息
- 1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院 胰胃外科,北京 100021
- 2. 山西医科大学第二临床学院,山西 太原 030001
- 3. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室,北京 100021
- 折叠
摘要
Abstract
As the powerhouse of cells,mitochondria plays an extremely important role in biological processes such as energy metabolism and cell death.Unlike other organelles,mitochondria contain unique DNA and are easily stimulated by many factors that lead to DNA damage.Damaged mitochondrial DNA can further cause changes in mitochondrial protein complexes and lead to the occurrence of tumor through various mechanisms such as reactive oxygen species.In order to maintain stable mitochondrial function,mitochondria have multiple mechanisms for repairing damage,which based on different degrees of damage.This process is called"mitochondrial quality control".The mechanisms of mitochondrial quality control mainly include mitochondrial derived vesicles,mitochondrial fusion/fission,and mitophagy,etc.This article provides an overview of different mitochondrial quality control mechanisms and their roles in tumor,and lists relevant functions of proteins which play important roles in mitochondrial quality control and tumor.In addition,mitochondria have extremely important translational medical prospects in the development of drug targets and tumor liquid biopsy biomarkers.It is believed that deeper exploration of mitochondrial function and related mechanisms can help solve the current problems in tumor research.关键词
线粒体质量控制/肿瘤/线粒体融合/线粒体裂变/线粒体自噬Key words
Mitochondrial quality control/Tumor/Mitochondrial fusion/Mitochondrial fission/Mitophagy引用本文复制引用
吴昀紫,郗博洲,马亮亮,杨鑫,解亦斌..线粒体质量控制与肿瘤研究进展[J].中国医学前沿杂志（电子版）,2024,16(2):78-87,10.
