利多卡因调节Hippo-YAP信号通路对原位肝移植大鼠缺血再灌注损伤的影响OACSTPCD
Effect of lidocaine regulating the Hippo-YAP signaling pathway on ischemia-reperfusion injury in orthotopic liver transplantation rats
目的 探究利多卡因(LID)对原位肝移植(OLT)大鼠缺血再灌注损伤的影响,并分析其作用机制.方法 随机将60只大鼠平均分为维替泊芬(Verteporfin)组、LID高剂量组、LID中剂量组、LID低剂量组、模型组和对照组,除对照组大鼠外的其余大鼠构建OLT模型.苏木素-伊红(HE)染色观察肝组织的病理变化,检测血清天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、乳酸脱氢酶(LDH)、丙氨酸氨基转移酶(ALT)活性,酶联免疫吸附试验(EL…查看全部>>
Objective To explore the effect of lidocaine(LID)on ischemia-reperfusion injury in orthotopic liver transplantation(OLT)rats and to analyze its mechanism of action.Methods Sixty rats were randomly divided into Verteporfin group,high-dose LID(High LID),medium-dose LID(Medium LID),low-dose LID(Low LID),Model and Control groups,on average.The rest of the rats except the control rats were used to establish OLT models.Observe the pathological changes in liver tis…查看全部>>
刘玥;艾克拜尔·努尔买买提;叶建荣
新疆医科大学第一附属医院麻醉科新疆围术期器官保护重点实验室,乌鲁木齐 830054新疆医科大学第一附属医院麻醉科新疆围术期器官保护重点实验室,乌鲁木齐 830054新疆医科大学第一附属医院麻醉科新疆围术期器官保护重点实验室,乌鲁木齐 830054
利多卡因原位肝移植缺血再灌注损伤Hippo-YAP信号通路炎症反应氧化应激凋亡
lidocaineorthotopic liver transplantationischemia-reperfusion injuryHippo-YAP signaling pathwayinflammatory responseoxidative stressapoptosis
《中国比较医学杂志》 2024 (2)
1-8,8
国家自然科学基金(82060581).
评论