中国医药科学2024，Vol.14Issue(6)：39-42,4.DOI:10.20116/j.issn2095-0616.2024.06.08
马钱子减毒增效途径及机制研究进展
Research progress on the pathways and mechanisms of reducing toxicity and enhancing efficacy of semen strychni
摘要
Abstract
This article reviews the research progress on the main pathways and mechanisms of reducing toxicity and enhancing efficacy of semen strychni.The main pathways of reducing toxicity and enhancing efficacy of semen strychni include processing,compatibility,new dosage forms,and new technology of preparations.The mechanisms of reducing toxicity and enhancing efficacy mainly include changes in the content of alkaloid components,changes in the pharmacokinetic behavior of alkaloids,effects on the mRNA expression and enzyme activity of CYP450 enzyme,induction of P-glycoprotein outward transport on the blood-brain barrier to accelerate alkaloid efflux,sustained release,and targeted control of drug concentration gradient.There are many studies on the pathways of reducing toxicity and enhancing efficacy of semen strychni,but researches on the mechanism and principles of reducing toxicity and enhancing efficacy are relatively few and not very in-depth.It is recommended that future research should conduct in-depth research on the mechanism of reducing toxicity and enhancing efficacy of semen strychni from the aspects of toxic substance basis,in vivo exposure and in vivo processes,molecular mechanisms,correlation of dose-time-toxicity-effect,and transformation patterns.关键词
马钱子/减毒增效/机制/炮制Key words
Semen strychni/Reduce toxicity and enhance efficiency/Mechanism/Processing分类
医药卫生引用本文复制引用
李艳,高粉粉,谈利红,朱照静,曾令高,毛景欣..马钱子减毒增效途径及机制研究进展[J].中国医药科学,2024,14(6):39-42,4.基金项目
重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0452). （cstc2021jcyj-msxmX0452）
