中国医药科学2024，Vol.14Issue(6)：43-46,63,5.DOI:10.20116/j.issn2095-0616.2024.06.09
炎性因子在妊娠期糖尿病发病中的作用研究进展
Research progress on the role of inflammatory factors in the pathogenesis of gestational diabetes mellitus
摘要
Abstract
Objective The incidence rate of gestational diabetes mellitus(GDM)is increasing year by year,which will increase the risk of cardiovascular complications in mothers and infants and threaten the safety of mothers and infants.The pathogenesis of GDM has not been fully elucidated,and with the progress of research,the role of immune-inflammatory disorders in the pathogenesis of GDM is increasingly being valued.The pathogenesis of GDM is related to the chronic inflammatory state in the patient's body.Most inflammatory factors not only participate in insulin resistance(IR),leading to GDM,but also damage the pancreatic β cells,promoting the development of GDM.This article reviews the mechanism of action of the main pro-inflammatory factors related to the pathogenesis of GDM,including interleukin(IL)-2,IL-6,tumor necrosis factor-α(TNF-α),IL-1 β,interferon-γ(IFN-y),C-reactive protein(CRP)and IL-17,and studies on their correlation with the pathogenesis of GDM,so as to provide a reference for the prevention and treatment of GDM.关键词
妊娠期糖尿病/炎性因子/胰岛素抵抗/胰岛β细胞功能障碍/发病机制Key words
Gestational diabetes mellitus/Inflammatory factors/Insulin resistance/Pancreatic β cell dysfunction/Pathogenesis分类
医药卫生引用本文复制引用
华景荷,葛莉,林钰铮,张辰钧,张梦婷,于红虹..炎性因子在妊娠期糖尿病发病中的作用研究进展[J].中国医药科学,2024,14(6):43-46,63,5.基金项目
福建省自然科学基金计划项目高校联合资助面上项目(2021J01945). （2021J01945）
