性别差异对牛Ⅱ型胶原诱导的类风湿关节炎模型的影响OACSTPCD
Effect of gender difference on the model of rheumatoid arthritis induced by bovine type Ⅱ collagen
目的 构建雌性及雄性牛Ⅱ胶原诱导的关节炎(collagen-induced arthritis,CIA)模型,比较性别差异对CIA模型关节及关节外表现的影响.方法 选用雌性及雄性SD大鼠并注射牛Ⅱ型胶原和弗氏完全佐剂诱导CIA模型,评估各组大鼠的一般情况、关节炎指数、足肿胀度、血清炎症因子及纤溶酶原激活物抑制剂水平、脾指数、膝关节及踝关节病理、右后足爪骨破坏情况、肺间质病变情况.结果 雌性CIA大鼠的关节炎指数在初次免疫后第21天较雄性CIA大鼠…查看全部>>
Objective To establish female and male bovine collagen-induced arthritis(CIA)models and compare the effects of gender differences on joint and extra-articular manifestations of the CIA model.Methods The CIA model was induced by injection of bovine type Ⅱ collagen and Freund's complete adjuvant into female and male SD rats.The general condition,arthritis index,foot swelling,serum proinflammatory factors and plasminogen activator inhibitor levels,spleen index,…查看全部>>
孙文婷;万盈盈;杨家熙;王文乾;王皓男;叶婉婷;寇秋爱
中国中医科学院西苑医院,北京 100091中国中医科学院西苑医院,北京 100091北京中医药大学,北京 100029北京中医药大学,北京 100029中国中医科学院西苑医院,北京 100091北京中医药大学,北京 100029中国中医科学院西苑医院,北京 100091
类风湿关节炎性别差异牛Ⅱ型胶原诱导的关节炎模型间质性肺病
rheumatoid arthritisgender differencearthritis induced by bovine type Ⅱ collageninterstitial lung disease
《中国比较医学杂志》 2024 (2)
25-34,10
中国中医科学院优势病种医院制剂新药研发专项(ZZ15-XY-PT-07).
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