雷公藤多苷致小鼠早发性卵巢功能不全模型的不同时间点进展研究OACSTPCD
Progression of Tripterygium wilfordii polyglycoside in mice with premature ovarian insufficiency at various time points
目的 探讨雷公藤多苷致早发性卵巢功能不全(POI)小鼠模型相关指标的变化,确定采取干预措施的最佳时间点.方法 将40只ICR雌性小鼠随机分为对照组、A、B、C、D模型组,每组8只.对照组灌胃纯水14 d(0.01 mL/10 g),其余各组给予雷公藤多苷混悬液(80 mg/kg,0.01 mL/10 g)分别连续灌胃1 d(A模型组)、3 d(B模型组)、7 d(C模型组)、14 d(D模型组),并分批次取材.称量各组小鼠体重、湿重子宫和双侧卵巢…查看全部>>
Objective Changes in relevant indexes in the mouse model of early-onset ovarian insufficiency caused by Tripterygium wilfordii polyglycoside were analyzed,and the optimal time point for intervention was determined.Methods Forty female ICR mice were randomly divided into control and A,B,C,and D model groups with eight mice in each group.The control group was gavaged with purified water for 14 days(0.01 mL/10 g),and the remaining groups were administered a Tri…查看全部>>
马林纳;马堃;范晓迪;罗洁;高山凤;李佳妮;张涵
天津中医药大学,天津 301617中国中医科学院西苑医院,北京 100091中国中医科学院西苑医院基础医学研究所,北京 100091中国中医科学院西苑医院,北京 100091中国中医科学院西苑医院,北京 100091中国中医科学院西苑医院,北京 100091天津中医药大学,天津 301617
早发性卵巢功能不全雷公藤多苷颗粒细胞血管新生病理性缺氧
premature ovarian insufficiencyTripterygium wilfordii polyglycosidegranule cellsangiogenesispathological hypoxia
《中国比较医学杂志》 2024 (2)
35-44,153,11
中国中医科学院科技创新工程项目(CI2021A02406)北京市自然科学基金(7212193)北京市科技计划(Z171100001017104).
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