中国医药科学2024，Vol.14Issue(6)：55-58,4.DOI:10.20116/j.issn2095-0616.2024.06.12
METTL16在肿瘤中的研究进展
Research progress of METTL16 in tumors
孙本乐 1路雪梅 1张美玲 1王霞1
作者信息
- 1. 滨州医学院口腔医学院,山东烟台 264003
- 折叠
摘要
Abstract
Methyltransferase 16(METTL16)is a newly discovered N6-methyladenosine(m6A)methyltransferase,which plays an increasingly prominent role in tumor research and has been confirmed to be abnormally expressed in various tumor diseases,playing varying degrees of regulatory roles.METTL16 can regulate the stability of target RNA by exerting the activity of methyltransferase,thereby exerting tumor-promoting or inhibiting effects in different tumors by influencing cell cycle transition,promoting glycolysis and inhibiting ferroptosis.However,there are also reports that METTL16 can promote translation by interacting with eukaryotic translation initiation factors,and promote the occurrence and development of tumors without relying on its methyltransferase activity.Therefore,METTL16 holds important value in the research of tumor diseases,and it is expected to become a new biomarker for early diagnosis and treatment of tumors.This review focuses on the research progress of METTL16 in the occurrence and development of tumors.关键词
N6-甲基腺苷/甲基转移酶16/肿瘤/生物标志物Key words
N6-methyladenosine/Methyltransferase 16/Tumor/Biomarkers分类
医药卫生引用本文复制引用
孙本乐,路雪梅,张美玲,王霞..METTL16在肿瘤中的研究进展[J].中国医药科学,2024,14(6):55-58,4.
