摘要
Abstract
Objective:To explore the clinical efficacy of Huaiqihuang granules combined with fiberoptic bronchoscopy(FOB)in the treatment of children with Mycoplasma pneumoniae pneumonia(MPP)and its effect on inflammatory factors and immune function.Methods:A total of 90 children with MPP who were treated in a certain hospital from June 2020 to July 2022 were divided into the FOB group and combination group by random number table method,with 45 patients in each group.Both groups were given conventional symptomatic treatment after admission such as expectorant,anti-tussive,antipyretic,fluid replacement therapies,the FOB group was given the FOB,the combination group was given Huaiqihuang granules in addition to the FOB,and both groups were treated continuously for 2 weeks.Thecytokines in alveolar lavage fluid[interleukin-8(IL-8),interleukin-17(IL-17),Toll-like receptor 2(TLR2)],immunoglobulins[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],T cell subsets(CD3+,CD8+,CD4+/CD8+),clinical response and adverse reactions were compared between the two groups.Results:After treatment,the levels of IL-8,IL-17 and TLR2 were decreased in both groups(P<0.05),and were lower in the combination group than those in the FOB group(P<0.05).The levels of IgA,IgG and IgM were increased in both groups(P<0.05),and were higher in the combination group than those in the FOB group(P<0.05).The levels of CD3+ and CD4+/CD8+ were increased in both groups(P<0.05),and were higher in the combination group than those in the FOB group(P<0.05).The level of CD8+ was decreased in both groups(P<0.05),and was lower in the combination group than that in the FOB group(P<0.05).The total response rate in the combination group(95.56%)was higher than that in the FOB group(77.78%,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions such as nausea,vomiting,irritant cough,chest tightness and abdominal pain between the two groups(P>0.05).Conclusion:Compared with FOB alone,Huaiqihuang granules combined with the FOB shows a definite clinical effect in the treatment of children with MPP with effectively relieved clinical symptoms,reduced levels of IL-8,IL-17 and TLR2,and improved immunity.关键词
槐杞黄颗粒/纤维支气管镜/儿童肺炎支原体肺炎/炎症因子/疗效Key words
Huaiqihuang granules/fiberoptic bronchoscopy/Mycoplasma pneumoniae pneumonia in children/inflammatory factors/efficacy分类
医药卫生
