中国比较医学杂志2024，Vol.34Issue(2)：154-160,7.DOI:10.3969/j.issn.1671-7856.2024.02.019
激光散斑衬比成像技术在慢性脑缺血动物模型中的应用研究进展
Advances in the application of laser speckle contrast imaging in animal models of chronic cerebral hypoperfusion
摘要
Abstract
A visual and quantitative method of dynamically measuring microcirculatory blood flow in a tissue or organ in real time was developed using laser speckle contrast imaging technology.It has been used in numerous microcirculation detection domains because of its benefits of in vivo detection,real-time imaging,and ease of operation.Most animal models of chronic cerebral hypoperfusion involve decreasing blood flow to the brain from bilateral common carotid arteries,which can lead to a protracted deficit in cerebral blood supply.By monitoring and analyzing cortical cerebral blood flow,collateral circulation opening,and neurovascular coupling responses,laser speckle contrast imaging technology assesses the efficacy of modeling and the therapeutic effect of interventions in animal models of chronic cerebral hypoperfusion.This article summarizes the benefits and drawbacks of laser speckle contrast imaging in an animal model of chronic cerebral hypoperfusion to promote novel approaches to clinical care and academic study.关键词
激光散斑衬比成像/慢性脑缺血/动物模型/综述Key words
laser speckle contrast imaging/chronic cerebral hypoperfusion/animal model/review分类
医药卫生引用本文复制引用
唐鑫,谭洁..激光散斑衬比成像技术在慢性脑缺血动物模型中的应用研究进展[J].中国比较医学杂志,2024,34(2):154-160,7.基金项目
湖南省教育厅科学研究重点项目(22A0253) （22A0253）
湖南省中医药科研计划项目(2021233). （2021233）
