中国卒中杂志2024，Vol.19Issue(3)：293-298,6.DOI:10.3969/j.issn.1673-5765.2024.03.007
高水平空腹血糖与缺血性卒中患者静脉溶栓后功能结局的关系分析
Relationship between High Levels of Fasting Blood Glucose and Functional Outcome after Intravenous Thrombolysis in Patients with Ischemic Stroke
丁则昱 1李光硕 1赵性泉2
作者信息
- 1. 北京 100070 首都医科大学附属北京天坛医院神经病学中心
- 2. 北京 100070 首都医科大学附属北京天坛医院神经病学中心||国家神经系统疾病临床医学研究中心
- 折叠
摘要
Abstract
Objective To investigate the association between fasting blood glucose and functional outcomes in ischemic stroke patients treated with intravenous thrombolysis.
Methods The study data of patients treated with intravenous thrombolysis in Beijing Tiantan Hospital,Capital Medical University from October 2018 to November 2020 were collected retrospectively.Ischemic stroke patients who received alteplase intravenous thrombolysis within 4.5 h of onset were included,and study data including fasting blood glucose were collected.The study outcome was set as a good functional outcome at discharge(mRS score 0-1).Multivariate logistic regression analysis was used to investigate the association between the fasting blood glucose and functional outcomes.
Results A total of 205 patients were enrolled.The mean age was(63.21±11.67)years.The percentage of male was 153(74.63％).The admission NIHSS score was 5(3-9).There were 117 patients(57.07％)who did not have a good functional outcome at discharge and 88 patients(42.93％)who did.Fasting blood glucose levels in patients with good functional outcomes were lower than those in patients with poor functional outcomes[5.10(4.46-7.06)mmol/L vs.6.33(5.09-7.79)mmol/L,P=0.001].Multivariate logistic regression analysis showed that after adjusting for age,gender,and NIHSS score,there was a correlation between fasting blood glucose level and the outcome of receiving intravenous thrombolysis(OR 0.876,95％CI 0.774-0.991,P=0.035).After adjusting for age,sex,NIHSS score and mechanical thrombectomy,the association was not statistically significant(OR 0.891,95％CI 0.791-1.004,P=0.058).
Conclusions In ischemic stroke patients undergoing intravenous thrombolysis,high level of fasting blood glucose may increase the risk of adverse discharge outcomes after intravenous thrombolysis.关键词
缺血性卒中/静脉溶栓/空腹血糖/功能预后Key words
Ischemic stroke/Intravenous thrombolysis/Fasting blood glucose/Functional outcome分类
医药卫生引用本文复制引用
丁则昱,李光硕,赵性泉..高水平空腹血糖与缺血性卒中患者静脉溶栓后功能结局的关系分析[J].中国卒中杂志,2024,19(3):293-298,6.
