中国医药科学2024，Vol.14Issue(6)：147-150,4.DOI:10.20116/j.issn2095-0616.2024.06.34
超声引导下FNAC联合BRAFV600e基因检测对甲状腺癌预后的价值研究
Study on the value of ultrasound-guided FNAC combined with BRAFV600e gene detection in the prognosis of thyroid cancer
摘要
Abstract
Objective To explore the clinical value of ultrasound-guided fine needle aspiration cytology(FNAC)combined with BRAFV600e gene detection in prognostic evaluation of thyroid cancer.Methods A total of 121 patients with suspected lymph node metastasis who were diagnosed with thyroid cancer and underwent radical surgery for thyroid cancer at Jingzhou Hospital Affiliated to Yangtze University from August 2020 to December 2022 were selected as the study subjects.All patients had received ultrasound-guided FNAC detection and BRAFV600e gene detection before surgery,and the postoperative pathological test results of the patients were used as the gold standard to calculate the diagnostic value of ultrasound-guided FNAC detection and BRAFV600e gene detection for lymph node metastasis in thyroid cancer.Results Using pathological results as the gold standard,the diagnostic consistency of FNAC guided by ultrasound for lymph node metastasis of thyroid cancer was 71.07％(86/121),the diagnostic sensitivity was 73.53％(75/102),and the diagnostic specificity was 57.89％(11/19).The diagnostic consistency of BRAFV600e gene detection for lymph node metastasis in thyroid cancer was 83.47％(101/121),the diagnostic sensitivity was 87.25％(89/102),and the diagnostic specificity was 63.16％(12/19).The diagnostic consistency of ultrasound-guided FNAC combined with BRAFV600e gene detection for lymph node metastasis in thyroid cancer was 97.52％(118/121),the diagnostic sensitivity was 98.04％(100/102),and the diagnostic specificity was 94.74％(18/19).The diagnostic consistency,sensitivity,and specificity of combined testing were significantly higher than those of any single detection method,with statistically significant differences between groups(P＜0.05).Conclusion Ultrasound-guided FNAC combined with BRAFV600e gene detection has good diagnostic efficacy for lymph node metastasis in thyroid cancer,which is superior to any single detection.It is recommended to apply it in the differential diagnosis of lymph node metastasis in thyroid cancer patients.关键词
超声引导/细针穿刺细胞学/BRAFV600e基因检测/甲状腺癌/淋巴结转移Key words
Ultrasound-guided/Fine needle aspiration cytology/BRAFV600e gene detection/Thyroid cancer/Lymph node metastasis分类
医药卫生引用本文复制引用
程诗露,胡锟,朱敏,黄龙凤..超声引导下FNAC联合BRAFV600e基因检测对甲状腺癌预后的价值研究[J].中国医药科学,2024,14(6):147-150,4.基金项目
湖北省荆州市医疗卫生科技计划项目(2016087). （2016087）
