中国合理用药探索2024，Vol.21Issue(3)：39-44,6.DOI:10.3969/j.issn.2096-3327.2024.03.007
益气固涩温脾汤加减辅助治疗结直肠癌根治术后吻合口瘘的临床研究
Clinical Study on Modified Yiqiguse Wenpi Decoction in Adjuvant Treatment of Anastomotic Leakage after Radical Resection of Colorectal Cancer
摘要
Abstract
Objective:To explore the clinical effect of modified Yiqiguse Wenpi decoction in the adjuvant treatment of anastomotic leakage after radical resection of colorectal cancer.Methods:52 patients with anastomotic leakage after radical resection of colorectal cancer,who were admitted to a certain hospital from January to December 2022,were divided into group A(n=24)and group B(n=28)by random number table method.The group A was treated with simple conventional symptomatic treatment such as cefoxitin sodium for injection,and the group B was treated with modified Yiqiguse Wenpi decoction in addition to the treatment given in the group A during the 3-week treatment.The healing time of anastomotic leakage,the time of recovery to normal diet,the length of hospital stay,symptom scores(anastomotic turbid fluid,severe abdominal pain,poor appetite,impaired bowel movement),clinical response and adverse reactions were compared between the two groups.Results:After treatment,the healing time of anastomotic leakage,the time of recovery to normal diet and the length of hospital stay in group B were shorter than those in the group A(P<0.05).The scores of anastomotic turbid fluid,severe abdominal pain,poor appetite and impaired bowel movement were decreased in both groups(P<0.05),and lower in the group B as compared with group A(P<0.05).The total response rate in group B(96.43%)was higher than that in group A(70.83%,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P=0.541).Conclusion:The simple conventional symptomatic treatment combined with modified Yiqiguse Wenpi decoction in the adjuvant treatment of patients with anastomotic leakage after radical resection of colorectal cancer has demonstrated definite clinical efficacy,with effectively improved clinical symptoms and reduced symptom scores,without additional risks of adverse reactions.关键词
益气固涩温脾汤/结直肠癌/根治术/吻合口瘘/临床疗效Key words
Yiqiguse Wenpi decoction/colorectal cancer/radical resection/anastomotic leakage/clinical efficacy分类
医药卫生引用本文复制引用
原志男,朱广灿,高宗跃..益气固涩温脾汤加减辅助治疗结直肠癌根治术后吻合口瘘的临床研究[J].中国合理用药探索,2024,21(3):39-44,6.基金项目
河南省中医药科学研究专项课题(2022ZY2027) （2022ZY2027）
