中国合理用药探索2024，Vol.21Issue(3)：50-56,7.DOI:10.3969/j.issn.2096-3327.2024.03.009
临床药师参与1例前列腺癌患者应用奥拉帕利致间质性肺炎伴发热的治疗实践
Clinical Pharmacists'Participation in the Treatment of Olaparib-Induced Interstitial Pneumonia with Fever in a Patient with Prostate Cancer
摘要
Abstract
Objective:To provide reference for pharmaceutical care in prostate cancer patients with olaparib-induced interstitial pneumonia and fever.Methods:The clinical pharmacists analyzed the diagnosis and treatment process of interstitial pneumonia experienced by a patient after oral administration of olaparib tablets based on the expertise on the clinical pharmacy in terms of the cause of fever and the treatment interventions of interstitial pneumonia,put forward the adjustments to the anti-tumor treatment regimen,and carried out the whole-process pharmaceutical care.Results:The dose discontinuation should be performed for the patient once upon the interstitial pneumonia,and the dose for the subsequent treatment should be adjusted according to the severity of adverse reactions.The symptoms of interstitial pneumonia of the patient were significantly improved during the participation of the clinical pharmacists in the diagnosis and treatment process.Conclusion:Although olaparib-induced interstitial pneumonia is rare,clinical pharmaceutical care should be highlighted to timely adjust medication regimen and provide symptomatic treatment,and meanwhile,the effect of drug interactions on the plasma concentration of olaparib should be paid attention to.关键词
奥拉帕利/间质性肺炎/发热/相互作用/药学监护/前列腺癌Key words
olaparib/interstitial pneumonia/fever/interaction/pharmaceutical care/prostate cancer分类
医药卫生引用本文复制引用
司倩,毛新奇,李文杰,杨庆宇,葛春丽..临床药师参与1例前列腺癌患者应用奥拉帕利致间质性肺炎伴发热的治疗实践[J].中国合理用药探索,2024,21(3):50-56,7.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20210709) （LHGJ20210709）
