中国合理用药探索2024，Vol.21Issue(3)：68-74,7.DOI:10.3969/j.issn.2096-3327.2024.03.012
小剂量复方倍他米松联合富血小板血浆在膝骨关节炎中的应用效果
Effect of Low-Dose Compound Betamethasone Combined with Platelet Rich Plasma in the Treatment of Knee Osteoarthritis
摘要
Abstract
Objective:To investigate the application effect of low-dose compound betamethasonein combined with platelet rich plasma(PRP)the treatment of knee osteoarthritis(KOA).Methods:92 patients with KOA and admitted to the hospital between December 2021 and December 2022 were selected and assigned into the control group and the observation group using a simple random grouping method,with 46 cases in each group.All patients received the conventional drug for KOA(glucosamine sulfate capsules).The control group received PRP treatment,while the observation group additionally received low-dose compound betamethasone injection.The pain status[visual analogue scale(VAS),knee function recovery status[Lysholm knee score scale(LKSS)],knee joint activity[range of motion(ROM),Western Ontario and Mcmaster Universitiy osteoarthritis index(WOMAC)],daily living ability[Barthel index(BI)],walking ability,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results:After treatment,the VAS score decreased in both groups(P<0.05),with the observation group having a lower score than the control group(P<0.05).The LKSS score increased in both groups(P<0.05),with the observation group scoring higher than the control group(P<0.05).Both groups showed enhanced active and passive ranges of motion(P<0.05),with the observation group demonstrating higher ranges of motion(P<0.05).The WOMAC score decreased(P<0.05),with the observation group scoring lower than the control group(P<0.05).Both groups showed increased scores in BI and walking ability(P<0.05),with the observation group scoring higher than the control group(P<0.05).The total effective rate of treatment in the observation group(95.65%)was significantly higher than that in the control group(80.43%,P<0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(χ2=0.212,P=0.646).Conclusion:The combination of PRP and low-dose compound betamethasone,in conjunction with conventional KOA drugs,demonstrates precise clinical efficacy in treating KOA patients.This treatment approach significantly reduces pain,enhances knee joint activity,promotes recovery of knee function,and improves daily living and walking abilities.关键词
富血小板血浆/复方倍他米松/膝骨关节炎/膝关节功能/日常生活能力/步行能力Key words
platelet rich plasma/compound betamethasone/knee osteoarthritis/knee function/ability of daily living/walking ability分类
医药卫生引用本文复制引用
任国强,明海武,董卫兵,庄卫生..小剂量复方倍他米松联合富血小板血浆在膝骨关节炎中的应用效果[J].中国合理用药探索,2024,21(3):68-74,7.基金项目
河南省卫生和计划生育委员会(202102310452) （202102310452）
