抗生素治疗慢性子宫内膜炎对反复移植失败妊娠结局的影响OACSTPCD

Objective To investigate the effect of antibiotic therapy on pregnancy outcome of patients undergoing recurrent implanta-tion failure combined with chronic endometritis.Methods A total of 168 patients with chronic endometritis who underwent recurrent trans-plant failure in the Seventh Medical Center of General Hospital of PLA from August 2020 to March 2022 were selected as the study subjects,and they were divided into the doxycycline group(n=84),the combined medication(levofloxacin and metronidazole)group(n=57),and the untreated group(n=45)according to whether treated with antibiotics before frozen-thawed embryo transfer and the kinds of antibiotics.The basic clinical data and the pregnancy outcome after frozen-thawed embryo transfer in the three groups were compared.Results There was no statistically significant difference in the age,BMI,infertility years,basal antral follicle count,basal follicle-stimulating hormone level,number of previous transfer cycles,or number of previous good-quality embryos transferred among the groups(P>0.05).There was no statistically significant difference in the endometrial preparation schemes,endometrial thickness on the conversion day,or number and type of transferred embryos among the groups(P>0.05).There was no statistically significant difference in the implantation rate,clinical pregnancy rate,or abortion rate among the groups(P>0.05).The live birth rates in the doxycycline group and the combined medication group were higher than that in the untreated group,with statistically significant differences(P<0.05);there was no statistically significant difference in the live birth rates between the doxycycline group and the combined medication group(P>0.05).Conclusion Antibiotic therapy can improve the live birth rates of patients undergoing recurrent implantation failure combined with chronic endometritis.