中国合理用药探索2024，Vol.21Issue(3)：92-100,9.DOI:10.3969/j.issn.2096-3327.2024.03.015
2015～2019年重庆某三甲医院革兰阴性杆菌的分布特点和耐药性变迁
Changes in Distribution Characteristics and Drug Resistance of Gram-Negative Bacilli in a Tertiary Hospital in Chongqing from 2015 to 2019
摘要
Abstract
Objective:To monitor the distribution and drug resistance of Gram-negative isolates from a hospital in Chongqing from 2015 to 2019.Methods:Specimens containing Gram-negative bacilli from a hospital in Chongqing submitted by Study for Monitoring Antimicrobial Resistance Trends(SMART)were used to perform antimicrobial susceptibility testing employing the custom sensitivity plate and Trek system.Results:A total of 950 Gram-negative isolates from patients with abdominal,respiratory,urinary,and bloodstream infections were collected.Among which,the detected Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii accounted for 43.37%,18.63%,14.11%and 10.84%,respectively.The resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa to conventional antimicrobials were high but without obvious changes from 2015 to 2019.The resistance rates of Klebsiella pneumoniae to third-generation cephalosporins and fluoroquinolones in 2017 increased significantly as compared with that in 2016,while the figure for resistance to carbapenems decreased to lower than 20%in 2019.In addition,there was a significant difference in the resistance rates of Gram-negative bacilli across infection sites.Among them,it was noted that high sensitivity rate of Acinetobacter baumannii obtained from urinary tract infection to both levofloxacin and colistin.However,in terms of abdominal and respiratory tract infections,the drug resistance rates were more than 50%.Fewer conventional antimicrobials are currently available for detected carbapenem-resistant Acinetobacter baumannii,cefotaxime-or ceftriaxone-resistant Escherichia coli,fluoroquinolone-resistant Escherichia coli,multidrug-resistant Acinetobacter baumannii,and multidrug-resistant Pseudomonas aeruginosa.Conclusion:The problem regarding the drug resistance of Gram-negative bacteria in the hospital from 2015 to 2019 was relatively prominent,particularly the third-generation cephalosporin-resistant germs in Enterobacterales order.The resistance rates of Acinetobacter baumannii to most antimicrobials is very high regardless of whether it is a special drug-resistant bacteria,which needs continuously monitoring and reference to clinical practice for reasonable selection of effective antimicrobials.关键词
革兰阴性杆菌/肠杆菌目细菌/不发酵糖革兰阴性杆菌/抗菌药物/耐药Key words
Gram-negative bacilli/germs in Enterobacterales order/non-fermentative Gram-negative bacilli/antibacterial drugs/drug resistance分类
医药卫生引用本文复制引用
代海峰,黄文祥,李佳俊,康纯鑫,贾蓓,辛小娟,阳成,刘成伟,唐君,陈潇迪..2015～2019年重庆某三甲医院革兰阴性杆菌的分布特点和耐药性变迁[J].中国合理用药探索,2024,21(3):92-100,9.基金项目
本研究由Merck Sharp&Dohme LLC(Merck&Co.,Inc.,Rahway,NJ,USA的子公司)及重庆市科技局自然科学基金(cstc2019jcyj-msxm0339)资助 （Merck&Co.,Inc.,Rahway,NJ,USA的子公司）
