中国医学前沿杂志（电子版）2024，Vol.16Issue(2)：27-33,7.DOI:10.12037/YXQY.2024.02-05
钠-葡萄糖共转运蛋白2抑制剂对射血分数保留心力衰竭中冠状动脉微血管功能障碍的影响
The effect of sodium-dependent glucose transporters 2 inhibitors on coronary microvascular dysfunction in heart failure with preserved ejection fraction
摘要
Abstract
Heart failure with preserved ejection fraction(HFpEF)accounts for approximately 50%of heart failure and shows an increasing trend.The pathogenesis of HFpEF is still not fully understood,and there is a lack of effective clinical treatment.Recent research evidence suggests that coronary microvascular dysfunction plays a crucial role in the occurrence and development of HFpEF.Numerous clinical trials have confirmed that sodium-dependent glucose transporters 2(SGLT2)inhibitors significantly improve the clinical prognosis of heart failure with reduced ejection fraction(HFrEF)patients and are independent of blood glucose control.They have been recommended as the basic treatment for HFrEF patients.SGLT2 inhibitors have a wide range of biological functions.Studies have confirmed that SGLT2 inhibitors can improve coronary microvascular function by inhibiting inflammation and oxidative stress,reducing insulin resistance,and maintaining endothelial function.At present,SGLT2 inhibitors are considered to be the ideal regimen for the treatment of HFpEF,although sufficient evidence-based medical evidence is still lacking.关键词
钠-葡萄糖共转运蛋白2抑制剂/冠状动脉微血管功能障碍/射血分数保留的心力衰竭Key words
Sodium-dependent glucose transporters 2 inhibitors/Coronary microvascular dysfunction/Heart failure with preserved ejection fraction引用本文复制引用
闫梦雯,周颖,任景怡..钠-葡萄糖共转运蛋白2抑制剂对射血分数保留心力衰竭中冠状动脉微血管功能障碍的影响[J].中国医学前沿杂志（电子版）,2024,16(2):27-33,7.基金项目
National High Level Hospital Clinical Research Funding(2023-NHLHCRF-YYPPLC-ZR-05),China-Japan Friendship Hospital"Elite Program"Talent Cultivation Project(ZRJY2021-BJ01) 中央高水平医院临床科研业务费资助(2023-NHLHCRF-YYPPLC-ZR-05) （2023-NHLHCRF-YYPPLC-ZR-05）
中日医院菁英项目(ZR-JY2021-BJ01) （ZR-JY2021-BJ01）
