摘要
Abstract
Objective To meta-analyze the clinical efficacy of ursodeoxycholic acid(UDCA)in the treatment of neonatal hyperbilirubinemia.Methods Studies from Chinese and English databases such as CNKI,Wanfang,VIP,PubMed/MEDLINE,and Scopus were retrived,randomized controlled trials of UDCA for the treatment of hyperbilirubinemia in newborns from 2010 to 2023 were selected.The quality of the literature was evaluated and relevant research data were extracted.Review Manager 5.4 statistical software was used to perform a meta-analysis on the selected literature to explore the clinical efficacy of UDCA combined with phototherapy in the treatment of neonatal hyperbilirubinemia.Results A total of 6 RCT articles that met the requirements were screened out in this study,including 1 Chinese article and 5 English articles.The control group in all the literature consisted of a total of 371 neonates who were treated with blue light irradiation,while the experimental group consisted of a total of 439 neonates who were treated with UDCA plus blue light irradiation.Heterogeneity analysis showed that when the I2 value of the literature was greater than 50%and the P value was less than 0.10,heterogeneity was present,and a random effects model was used for analysis.The results of the meta-analysis showed that the total bilirubin levels in the experimental group neonates were significantly lower than those in the control group neonates at 12,24,48,and 72 hours after treatment(P<0.05);and the duration of phototherapy in the experimental group neonates was also significantly shorter than that in the control group(MD=-19.15,95%CI:-20.80,-17.50,P<0.01).Conclusions Compared with traditional blue light irradiation for neonatal hyperbilirubinemia,combined with UDCA treatment can further promote the reduction of total bilirubin level and reduce the time of phototherapy.关键词
新生儿/高胆红素血症/蓝光照射/熊去氧胆酸/疗效Key words
Neonates/Hyperbilirubinemia/Blue light irradiation/Ursodeoxycholic acid/Efficacy
