中外医学研究2024，Vol.22Issue(8)：66-70,5.DOI:10.14033/j.cnki.cfmr.2024.08.017
脑出血术后患者的纤溶系统与免疫炎症反应关系的研究
Study on Correlation between Fibrinolytic System and Immune Inflammatory Response of Postoperative Patients with Cerebral Hemorrhage
摘要
Abstract
Objective:To investigate the correlation between fibrinolytic system and immune inflammatory response of postoperative patients with cerebral hemorrhage.Method:A total of 240 postoperative patients with cerebral hemorrhage who treated in Cardiovascular and Cerebrovascular Hospital of General Hospital of Ningxia Medical University from September 2020 to December 2022 were selected as the study objects,they were divided into conscious group,sleepiness group,lethargy group,light coma group,medium coma group and deep coma group according to the degree of consciousness impairment at the first day after surgery,with 40 cases in each group.Then the lymphocyte immunity indexes(CD3+,CD4+,CD8+,CD4+/CD8+ and CD19+),fibrinolytic indexes[fibrinogen(FIB),fibrinogen degradation products(FDP)and D-dimer(D-D)],inflammatory indexes(monocytes,neutrophils,lymphocytes,neutrophil/lymphocyte and platelet/monocyte)of six groups were detected and compared,and pearson correlation analysis was used to analyze the relationship between fibrinolytic indexes and lymphocyte immunity indexes and inflammatory indexes.Result:There were no significant differences in the lymphocyte immunity indexes,lymphocytes and platelet/monocyte between conscious group and sleepiness group(P>0.05);there were significant differences in other indexes among six groups(P<0.05);the CD3+,CD4+,CD4+/CD8+,CD19+ and lymphocytes of deep coma group were lowest,and the CD8+,fibrinolytic indexes and other inflammatory indexes were highest,the next were medium coma group,light coma group,lethargy group and sleepiness group.Pearson correlation analysis showed the fibrinolytic indexes were negatively correlated with lymphocytes,CD3+,CD4+,CD4+/CD8+,CD19+(P<0.05),and were positively correlated with CD8+,monocytes,neutrophils,neutrophil/lymphocyte and platelet/monocyte(P<0.05).Conclusion:The differences of fibrinolytic system and immune inflammatory response of postoperative patients with cerebral hemorrhage of different degree of consciousness impairment are significant,and they have close relationship,so their detection value in the surgical patients with cerebral hemorrhage are higher.关键词
脑出血/手术/纤溶系统/免疫状态/炎症反应Key words
Cerebral hemorrhage/Surgery/Fibrinolytic system/Immune state/Inflammatory response引用本文复制引用
姚再先,梁婷,杨波..脑出血术后患者的纤溶系统与免疫炎症反应关系的研究[J].中外医学研究,2024,22(8):66-70,5.基金项目
2020年宁夏回族自治区卫生健康委科研课题项目(宁卫办发(2020)256号) （宁卫办发(2020）
