摘要
Abstract
Objective:To investigate the effect of quadruple therapy combined with digestive endoscopy in the treatment of peptic ulcer bleeding(PUB)and its influence on coagulation index.Method:A total of 76 PUB patients admitted to Cenxi People's Hospital from June 2022 to May 2023 were selected and divided into combined group and conventional group according to different treatment plans,with 38 cases in each group.The conventional group was treated with quadruple therapy,and the combined group was treated with digestive endoscopy on the basis of quadruple therapy.The therapeutic effect of the two groups was compared.Result:The amount of blood loss in the combined group was less than that in the conventional group,and the time of hemostasis and ulcer healing were earlier than those in the conventional group,the differences were statistically significant(P＜0.05).After treatment,the thrombin time(TT),prothrombin time(PT),D-dimer(D-D)and international normalized ratio(INR)in the two groups were all lower than those before treatment,and the indexes in the combined group were lower than those in the conventional group,the differences were statistically significant(P＜0.05).Before treatment,there was no significant difference in gastrin-17 level between the two groups(P＞0.05).After treatment,the levels of gastrin-17 in both groups were higher than those before treatment,and the combined group was significantly higher than that in the conventional group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in combined group was lower than that in conventional group,and the difference was statistically significant(P＜0.05).Conclusion:The effect of quadruple therapy combined with digestive endoscopy in the treatment of PUB is exact,which can effectively improve the body's coagulation function,rapidly stop bleeding to reduce the amount of blood loss,low incidence of adverse reactions,and high safety.关键词
消化性溃疡出血/消化内镜治疗/四联疗法/凝血指标Key words
Peptic ulcer bleeding/Digestive endoscopic therapy/Quadruple therapy/Coagulation index
