中外医学研究2024，Vol.22Issue(7)：155-159,5.DOI:10.14033/j.cnki.cfmr.2024.07.039
硫酸吲哚酚对肌少症信号通路及CKD患者肌细胞的影响
Effect of Indoxyl-sulfate on Sarcopenia Signaling Pathways and Muscle Cells in Patients with CKD
摘要
Abstract
Sarcopenia is one of the common complications in patients with chronic kidney disease(CKD),it is mainly a clinical complication of muscle mass,weight and function abnormalities and muscle atrophy caused by insufficient protein intake,reduced activity and chronic inflammation.Indoxyl-sulfate(IS),as a protein-bound uremic toxin,is not easy to be removed by clinical drugs and renal replacement therapy,it can affect multiple sarcopenic pathways and mechanisms by regulating various signaling factors and cause damage to skeletal muscle cells.This article summarized the main signaling pathways and mechanisms of sarcopenia,and explored how IS leads to mitochondrial dysfunction,skeletal muscle cell atrophy,fibrosis and other pathological conditions,leading to sarcopenia in CKD patients.By summarizing the main signaling pathways and mechanisms of sarcopenia,this paper explores how IS causes mitochondrial dysfunction,skeletal muscle cell atrophy and fibrosis.关键词
肌少症/硫酸吲哚酚/慢性肾脏病/肌细胞/信号通路Key words
Sarcopenia/Indoxyl-sulfate/Chronic kidney disease/Muscle cells/Signaling pathways引用本文复制引用
黄诗琦,崔师妍,徐鹏昊,姜晨..硫酸吲哚酚对肌少症信号通路及CKD患者肌细胞的影响[J].中外医学研究,2024,22(7):155-159,5.基金项目
天津市科技计划项目(A1105) （A1105）
