摘要
Abstract
Objective:To investigate the effect of Meek skin grafting combined with nano-silver dressing in the treatment of extensive burn patients.Method:The clinical data of 80 patients with extensive burn treated in Nantong First People's Hospital from July 2021 to July 2023 were retrospectively analyzed and divided into control group and observation group according to different treatment methods,with 40 cases in each group.The control group was treated with Meek skin grafting,and the observation group was treated with nano-silver dressing on the basis of control group.The clinical efficacy,matrix metalloproteinases(MMPs)level,inflammatory factor level and complication rate of the two groups were compared.Result:The wound healing rate and skin survival rate of the observation group were higher than those of the control group,and the wound healing time and skin fusion time of the observation group were shorter than those of the control group,the differences were statistically significant(P<0.05).After treatment,tissue inhibitor of metalloproteinases 1(TIMP-1)in both groups were higher than those before treatment,matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-2(MMP-2)were lower than those before treatment,and TIMP-1 in the observation group was higher than that of the control group,and MMP-1 and MMP-2 were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in two groups were lower than those before treatment,interleukin-10(IL-10)were higher than those before treatment,and IL-6 and TNF-α in observation group were lower than those in control group,and IL-10 in observation group was higher than that in control group,the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Meek skin grafting combined with nano-silver dressing can promote wound healing in patients with extensive burn,inhibit the expression of MMPs,reduce inflammatory response and reduce complications.关键词
Meek植皮术/纳米银敷料/大面积烧伤/基质金属蛋白酶Key words
Meek skin grafting/Nano-silver dressing/Extensive burn/Matrix metalloproteinase
