基于"伏邪理论"探讨CAC发病中TAMs/MUC1介导的结肠炎性微环境形成机制OACSTPCD

Inflammatory microenvironment plays a crucial role in the process of"inflammation-cancer"transformation of colon.The transformation process mediated by the inflammatory microenvironment is similar to the theory of'Latent pathogen'in traditional Chinese medicine(TCM).Based on the theory of'Latent pathogen',this paper explores the mechanism of colonic inflammatory microenvironment formation mediated by the relationship between TAMs and MUC1,and we believe that abnormal expression of MUC1 could be used as an indicator for the study of"latent phlegm".It is also suggested that in the clinical prevention and treatment of colitis-associated colorectal cancer(CAC),the basic principle should be outthrusting the pathogen.Furthermore,flexibly applying such treatment methods as fortifying spleen and resolving phlegm,regulating qi,clearing warm pathogen,and promoting blood circulation and detoxification is also helpful.