中外医学研究2024，Vol.22Issue(9)：177-180,4.DOI:10.14033/j.cnki.cfmr.2024.09.044
微小分子RNA在再生障碍性贫血中的作用及研究进展
Role and Research Progress of MicroRNA in Aplastic Anemia
摘要
Abstract
Aplastic anemia(AA)is a bone marrow hematopoietic failure syndrome characterized by pancytopenia.Hyperfunction of T cells and abnormal bone marrow microenvironment are the main factors of its pathogenesis.Micro RNA(miRNA)are conserved small non-coding RNA,which are involved in the regulation of pathophysiological processes of various diseases and play an important role in the regulation of T cell immunity and lipogenic osteogenic differentiation of bone marrow mesenchymal stem cells(BM-MSCs).It has been confirmed that miRNA participate in the occurrence and development of AA,and targeted therapy based on miRNA may become the direction of AA treatment in the future.In this review,the role of miRNA in T cell function and lipid osteogenic differentiation of BM-MSCs in AA was reviewed.关键词
再生障碍性贫血/微小分子RNA/T细胞功能/骨髓微环境/间充质干细胞Key words
Aplastic anemia/Micro RNA/T cell function/Bone marrow microenvironment/Mesenchymal stem cells引用本文复制引用
耿雪银,李步霓,左华芹,王方方..微小分子RNA在再生障碍性贫血中的作用及研究进展[J].中外医学研究,2024,22(9):177-180,4.基金项目
扬州市科技计划项目(YZ2022068) （YZ2022068）
