盐酸氨溴索联合替考拉宁治疗ICU革兰阳性菌感染VAP患者的效果OA
Efficacy of Ambroxol Hydrochloride Combined with Teicoplanin in the Treatment of Gram-positive Bacterial Infection VAP Patients in ICU
目的:探讨盐酸氨溴索联合替考拉宁治疗重症监护病房(Intensive Care Unit,ICU)革兰阳性菌感染呼吸机相关性肺炎(ventilator-associated pneumonia,VAP)患者的效果.方法:选取 2019 年 1 月—2020 年 12 月贵航贵阳医院收治的120 例ICU革兰阳性菌感染VAP患者.根据随机数表法将其分为对照组和观察组,各 60 例.对照组给予常规抗感染治疗,观察组在对照组基础上给予盐酸氨溴索联合替考拉宁治疗.比较两组临床疗效,相关指标,不良反应,治疗前后免疫指标.结果:观察组总有效率为 93.33%,显著高于对照组的 76.67%,差异有统计学意义(P<0.05).观察组恢复时间、住院时间均短于对照组,总费用少于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).治疗后,观察组CD3+、CD4+、CD4+/CD8+水平显著高于治疗前及对照组,CD8+水平显著低于治疗前及对照组,差异有统计学意义(P<0.05).结论:盐酸氨溴索联合替考拉宁能够提高ICU革兰阳性菌感染VAP患者的临床疗效,缩短恢复时间及住院时间,降低费用,同时能够增强机体免疫功能,调节T淋巴细胞亚群水平,具有较好的安全性和耐受性.
Objective:To investigate the efficacy of Ambroxol Hydrochloride combined with Teicoplanin in the treatment of Gram-positive bacterial infection ventilator-associated pneumonia(VAP)patients in Intensive Care Unit(ICU).Method:A total of 120 ICU Gram-positive bacterial infection VAP patients admitted to Guihang Guiyang Hospital from January 2019 to December 2020 were selected.They were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was given routine anti-infection treatment,and the observation group was given Ambroxol Hydrochloride combined with Teicoplanin on the basis of the control group.The clinical efficacy,related indexes,adverse reactions,and immune indexes before and after treatment were compared between the two groups.Result:The total effective rate of the observation group was 93.33%,which was significantly higher than 76.67%of the control group,and the difference was statistically significant(P<0.05).The recovery time and hospitalization time in the observation group were shorter than those in the control group,and the total cost was less than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of CD3+,CD4+,CD4+/CD8+ in observation group were significantly higher than those before treatment and control group,and CD8+ level was significantly lower than that before treatment and control group,the differences were statistically significant(P<0.05).Conclusion:Ambroxol Hydrochloride combined with Teicoplanin in the treatment of Gram-positive bacterial infection VAP patients can improve the clinical efficacy,shorten the recovery time and hospitalization time,and reduce the cost of ICU.At the same time,it can enhance the immune function of the body,regulate the level of T lymphocyte subgroups,and have good safety and tolerance.
陈亚飞
贵航贵阳医院 贵州 贵阳 550001
盐酸氨溴索替考拉宁革兰阳性菌呼吸机相关性肺炎T淋巴细胞亚群
Ambroxol HydrochlorideTeicoplaninGram-positive bacteriaVentilator-associated pneumoniaT lymphocyte subsets
《中外医学研究》 2024 (006)
48-51 / 4
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