吉林大学学报（医学版）2024，Vol.50Issue(2)：556-563,8.DOI:10.13481/j.1671-587X.20240232
角化龈形成机制及增量移植材料的研究进展
Research progress in formation mechanism of keratinized gingiva and incremental transplant material
摘要
Abstract
Keratinized gingiva plays an important role in maintaining the health of the periodontal tissue,however,the specific mechanism of its formation is not fully understood.The differentiation of oral epithelial cells is determined by genetics,but the type of epithelium is also influenced by the underlying connective tissue and periodontal ligament,and the elastic fibers in the connective tissue has an important indirect effect on maintaining the epithelial phenotype.Due to the unclear formation mechanism,the primary treatment method for augmenting keratinized gingiva is currently mucogingival surgery,and the employing graft materials included autogenous tissues(free gingival grafts,subepithelial connective tissue grafts,and autologous platelet concentrates,etc),allogeneic materials(acellular dermal matrix,xenogeneic collagen matrix,and amniotic membrane,etc.)and the combination of these in the form of tissue-engineered products(using layered chitosan or nanofiber hydrogel composite materials as scaffolds).This review covers the keratinization process of the gingiva,the factors determining keratinization,and the existing graft materials,summarizes the current research advancements in gingival keratinization mechanism and materials for gingival augmentation,and provides the basis for the further mechanism research and the development of new materials.关键词
角化龈/上皮下结缔组织/细胞分化/牙周软组织再生/移植材料Key words
Keratinized gingiva/Subepithelial connective tissue/Cell differentiation/Gingival soft tissue regeneration/Graft material分类
医药卫生引用本文复制引用
石雅茹,杨庆祎,徐晓薇..角化龈形成机制及增量移植材料的研究进展[J].吉林大学学报（医学版）,2024,50(2):556-563,8.基金项目
国家自然科学基金面上项目(81970946) （81970946）
吉林省科技厅自然科学基金项目(20200201611JC) （20200201611JC）
吉林大学学科交叉融合创新项目(JLUXKJC2021QZ09) （JLUXKJC2021QZ09）
吉林大学白求恩计划项目(2020B43) （2020B43）
