14-3-3ɛ蛋白与肿瘤发生发展关系的研究进展OA北大核心CSTPCD

14-3-3ε protein,also known as YWHAE protein,is a member of the 14-3-3 protein family characterized by a small relative molecular weight.Unlike protein kinases,14-3-3ε protein does not participate in protein phosphorylation within the cells;instead,it forms the unique dimer structures and binds to the specific phosphorylated proteins,thereby regulating the activity and subcellular localization of the protein ligands and playing a role in the regulation of various cellular activities.The aberrant expression of 14-3-3ε protein has been discovered in the numerous cancers.The altered regulatory effect of aberrantly expressed 14-3-3ε protein on its protein ligands can affect the ligands'subcellular localization and enzymatic activity,leading to the development,invasion,and metastasis of the tumor cells.The dimer structure of 14-3-3ε protein is a critical structural basis for its biological functions in the tumor progression,and disrupting the dimer structure could be targeted to kill the tumor cells.This review is based on the domestic and international research findings on the 14-3-3ε protein and covers its structure,mechanism,and the impact and mechanisms during the development process of gastric cancer,liver cancer,skin cancer,and various other tumors.