心脏磁共振特征追踪技术定量评价COPD左心室功能异常的研究OA北大核心CSTPCD

Objective:To quantitatively evaluate the global and segmental subclinical myocardial dysfunction of the left ventricle in patients with chronic obstructive pulmonary disease(COPD)by cardiovascular magnetic resonance feature tracking(CMR-FT).Materials and Methods:A total of 47 COPD patients(including 25 males and 22 females)with an average age of 47.26±4.66 who have met the inclusion and exclusion criteria in our hospital from October 2021 to February 2023 are retrospective collected.Twenty-eight COPD patients showed no significant abnormalities in the coronary arteries,while 19 COPD patients had mild coronary artery stenosis(stenosis rate<50%).In the meantime,30 healthy volunteers matched for age,gender,and smoking habits(including 17 males and 13 females)with an average age of 47.47±4.42 were included as the normal control group.All participants underwent 3.0 T CMR examination to analyze the differences between the COPD group and the normal control group in left ventricular conventional cardiac function,the peak strain(PS)in all directions(radial,circumferential and longitudinal)of the global and segmental myocardium.Due to the high incidence of cardiovascular disease in COPD patients,we conducted subgroup analysis on the global and segmental PS in all directions of the left ventricle in patients with normal coronary arteries and mild coronary stenosis.Independent sample t-test was used to compare data between two groups that follow a normal distribution.Mann-Whitney U test was used to compare the data between the two groups that did not conform to the normal distribution.The χ2 test was used for gender comparison between the two groups.Results:The left ventricular PS of the global,middle segment and basal segment in all directions in COPD group was lower than that in the normal control group(all P<0.05),the apical segment radial and longitudinal PS were significantly lower than that in the normal control group,and there was no significant difference in the apical segment circumferential PS compared with that in the normal control group(P= 0.268).In subgroup analysis,there was no significant difference in the left ventricle PS of the global,apical segment,middle segment and basal segment in all directions between COPD patients with mild coronary artery stenosis and those with normal coronary arteries(all P>0.05).Conclusions:The use of CMR-FT can quantitatively evaluate the global and segmental subclinical myocardial dysfunction of the left ventricle in COPD patients,and its myocardial injury is caused by COPD itself.CMR-FT is expected to provide imaging basis for early diagnosis and prognostic evaluation of diseases.