磁共振成像2024，Vol.15Issue(4)：99-105,7.DOI:10.12015/issn.1674-8034.2024.04.016
MAGiC技术定量评估原发性骨质疏松症的可行性研究
Feasibility study of the MAGiC technique for quantitative assessment of primary osteoporosis
摘要
Abstract
Objective:To evaluate the application value of magnetic resonance image compilation(MAGiC)sequence in primary osteoporosis.Materials and Methods:Prospectively recruited health screening volunteers who completed a low-dose chest CT scans between May 2023 and September 2023.All volunteers voluntarily underwent routine lumbar MRI and MAGiC sequence scans.The average bone mineral density(BMD)value of the lumbar spine based on low-dose chest CT,the VBQ value based on conventional T1-weighted imaging,and the VBQ-magic,average T1 relaxation time(T1av),average T2 relaxation time(T2av),average proton density(PDav)values based on MAGiC T1-weighted imaging were measured,and the body mass index(BMI)value was calculated.Patients were categorized into a normal bone group(63 cases),a bone loss group(43 cases),and an osteoporosis group(22 cases)based on the osteoporosis diagnostic criteria of lumbar quantitative computed tomography(QCT).Multiple group comparisons were performed using one-way ANOVA or Kruskal-Wallis test.Pairwise comparisons were conducted using either LSD test or Wilcoxon test.The correlations between each parameter and BMD were examined using Pearson or Spearman correlation analysis.Receiver operating characteristic(ROC)curves were employed to evaluate the diagnostic efficacy of single and combined parameters for bone loss and osteoporosis.Results:The differences in age,VBQ,VBQ-magic,T1av,T2av,and PDav values among the three groups were statistically significant(P<0.05).The VBQ-magic values for the normal bone group,bone loss group,and osteoporosis group were 2.92(2.71,3.11),3.16(2.87,3.40),and 3.37(3.19,3.53),respectively,the differences between each pair of groups were statistically significant(P≤0.009).The T1av values were 622.80(554.80,692.00)ms,565.40(538.00,599.20)ms,and 560.50(515.80,586.55)ms,respectively,the differences between the normal bone group and the bone loss group,as well as the osteoporosis group,were statistically significant(P=0.001 for both).The T2av values were(75.40±6.06)ms,(77.05±5.95)ms,and(84.79±5.36)ms,respectively,the differences among the normal bone group,bone loss group,and osteoporosis group were statistically significant(P<0.001 for both).The PDav value of the normal bone group was less than that of the bone loss group and osteoporosis group(P=0.007,0.043).There was a moderate correlation between VBQ-magic,T1av,and BMD values(r=-0.524,0.403),while T2av and PDav showed a weak correlation with BMD values(r=-0.365,-0.224).The areas under the curve(AUC)for VBQ-magic,T1av,and VBQ-magic+T1av in distinguishing bone loss were 0.772,0.702,and 0.782,respectively.The diagnostic efficacy of VBQ-magic alone and combined with T1av showed no statistically significant difference from VBQ(P>0.05).The AUCs for VBQ-magic,T2av,and VBQ-magic+T2av in distinguishing osteoporosis were 0.810,0.867,and 0.803,respectively.The diagnostic efficacy of VBQ-magic alone and combined with T2av showed no statistically significant difference from VBQ(P>0.05).Conclusions:The VBQ scoring based on MAGiC T1-weighted images and the T1 and T2 values have a certain predictive ability for bone loss and osteoporosis,providing new diagnostic methods and reference indices for osteoporosis.关键词
骨质疏松症/骨质量/骨密度/磁共振成像/定量磁共振成像Key words
osteoporosis/vertebral bone quality/bone mineral densitym/agnetic resonance imaging/quantitative magnetic resonance imaging分类
医药卫生引用本文复制引用
王文娟,邹月芬,胡磊,刘啸峰,柴刘勇..MAGiC技术定量评估原发性骨质疏松症的可行性研究[J].磁共振成像,2024,15(4):99-105,7.基金项目
Chizhou City 2023 Scientific and Technological Research Projects in the Field of Social Development(No.CZ23KJSFy012). 池州市2023年度社会发展领域科技攻关项目(编号:CZ23KJSFy012) （No.CZ23KJSFy012）
