磁共振成像2024，Vol.15Issue(4)：197-206,10.DOI:10.12015/issn.1674-8034.2024.04.033
基于扩散磁共振成像的脑组织微结构成像在脑肿瘤诊疗中的应用
The application of diffusion magnetic resonance imaging-based brain tissue microstructure imaging in the diagnosis and treatment of brain tumors
摘要
Abstract
Diffusion MRI(dMRI)is an imaging technique that utilizes signal contrast generated by the changes in degree and direction of water molecules during the diffusion process.The effectiveness of dMRI primarily relies on the acquisition of MR signals and the fitting models employed.dMRI has significant applications in non-invasively revealing the microstructural features of brain tissue and brain diseases.In recent years,innovative diffusion encoding models such as multidimensional diffusion(MDD),novel signal models such as mean apparent propagator MRI(MAP-MRI),and new compartment models such as neurite orientation dispersion and density imaging(NODDI),have been continuously proposed,which have greatly propelled the advancement of brain tissue microstructure imaging techniques.This article offers a comprehensive review of the current advancements in diverse brain tissue microstructure imaging technologies utilizing dMRI,focusing on signal acquisition and model fitting.It explores their initial use in prevalent brain tumors like gliomas and brain metastases,emphasizing clinical concerns such as distinguishing between different types of tumors,determining tumor grades,molecular subtyping,evaluating treatment effectiveness,and predicting patient prognosis.Moving forward,there is a need to enhance the imaging parameters of dMRI-based brain tissue microstructure imaging technologies by optimizing factors like b-value ranges and imaging duration.Moreover,further research and comparison are required to assess the utility of various innovative brain tissue microstructure imaging technologies in addressing the aforementioned critical clinical issues.The goal is to advance the development and clinical implementation of dMRI-based brain tissue microstructure imaging technologies,uncovering the unique features of brain tumors from a microscopic morphology perspective and providing substantial evidence for early diagnosis,differential diagnosis,tumor grading,molecular subtyping,and prognosis forecasting in brain tumor cases.关键词
脑肿瘤/扩散磁共振成像/磁共振成像/扩散编码/信号模型/隔室模型Key words
brain neoplasms/diffusion magnetic resonance imaging/magnetic resonance imaging/diffusion encoding/signal model/compartment model分类
临床医学引用本文复制引用
胡芷瑄,毛椿平,王梦珠,严序,毛家骥,沈君..基于扩散磁共振成像的脑组织微结构成像在脑肿瘤诊疗中的应用[J].磁共振成像,2024,15(4):197-206,10.基金项目
National Key Research and Development Program(No.2022YFA1104800). 国家重点研发计划项目(编号:2022YFA1104800) （No.2022YFA1104800）
