重庆医学2024，Vol.53Issue(7)：1016-1020,1026,6.DOI:10.3969/j.issn.1671-8348.2024.07.010
左、右半结肠癌患者分子生物学与临床病理特征分析
Analysis on molecular biology and clinical pathological characteristics in patients with left and right hemicolon cancer
摘要
Abstract
Objective To compare the results of the next generation sequencing gene testing and clini-copathological characteristics in the patients with left hemicolon cancer(LCC)and right hemicolon cancer(RCC).Methods The next generation sequencing gene testing results and clinical pathological data of 335 pa-tients with colon cancer in the Molecular Diagnosis Center of this hospital from January 2022 to June 2023 were collected retrospectively.The molecular biological and clinical characteristics of LCC and RCC were ana-lyzed.Results Among 335 patients,263 cases were LCC and 72 cases were RCC.The proportions of tumors maximal diameter ≥5 cm,gene mutation rates of BRAF,PTEN,PIK3CA and SMAD4,and microsatellite in-stability-high(MSI)in the patients with RCC were higher than those in the patients with LCC(44.44％vs.14.83％,8.33％vs.3.04％,12.50％vs.3.80％,26.39％vs.10.65％,16.90％vs.9.47％,13.89％vs.1.52％,P＜0.05),the TP53 gene mutation rate was lower(66.67％vs.82.51％),and the differences were statistically significant(P＜0.05).Conclusion There are differences in molecular biology and pathological characteristics between the patients with LCC and the patient with RCC.关键词
左右半结肠癌/二代测序/基因突变/分子生物学特征/临床病理特征Key words
left and right hemicolon cancer/second generation sequencing/gene mutations/molecular biological characteristics/clinical pathological features分类
医药卫生引用本文复制引用
韩婷婷,刘馨,王晓雄,李鸿生,蔡静静,李卓颖,郭银金,杨锐娇,周永春..左、右半结肠癌患者分子生物学与临床病理特征分析[J].重庆医学,2024,53(7):1016-1020,1026,6.基金项目
国家自然科学基金项目(81860513) （81860513）
云南省教育厅科学研究基金项目(2023Y0598). （2023Y0598）
