急性化脓性扁桃体炎患儿血清淀粉样蛋白A、白细胞介素6及降钙素原的表达及临床意义OACSTPCD

OBJECTIVE To investigate the expression and clinical significance of serum amyloid A,interleukin-6 and procalcitonin in children with acute suppurative tonsillitis(AST).METHODS A total of 80 children with AST who visited the Third Affiliated Hospital of Xi'an Medical University from January 2022 to June 2023 were included in the observation group.According to the different pathogens infected,they were divided into the virus infection group(35 cases)and the bacterial infection group(45 cases).Another 30 healthy children undergoing physical examination were selected as the control group.The serum levels of SAA,IL-6 and PCT in each group were detected and compared,and the ROC curves were used to analyze the diagnostic value of SAA,IL-6 and PCT for AST.RESULTS Compared with the control group,the average levels of serum SAA,PCT and IL-6 in the observation group were significantly higher[(104.86±30.47)mg/L vs.(8.27±1.09)mg/L,(21.39±6.24)ng/L vs.(4.45±1.21)ng/L,(73.98±17.34)ng/L vs.(5.07±1.86)ng/L,P<0.05].Compared with the bacterial infection group,the serum IL-6 level in the viral infection group was significantly increased[(87.61±19.22)ng/L vs.(63.75±8.13)ng/L,P<0.05].The serum SAA and PCT levels in the bacterial infection group were higher than those in the viral infection group[(86.73±14.65)mg/L vs.(154.69±39.76)mg/L,(15.27±3.09)ng/L vs.(47.28±6.27)ng/L,P<0.05].The AUC of serum SAA for diagnosing viral AST was 0.821(95%CI:0.749-0.902,P=0.001),and the sensitivity was 88.67%,and the specificity was 75.94%.The sensitivity and specificity of PCT combined with IL-6 in diagnosing bacterial infectious were high.The combined detection of SAA and PCT has high sensitivity and specificity for the diagnosis of bacterial infectious AST,and it was 92.08%and 79.35%(P<0.05).CONCLUSION The expression of serum SAA,PCT and IL-6 in the serum of children with AST are increased,and it has important value in the clinical diagnosis of viral infectious AST and bacterial infectious AST.