肝胆胰外科杂志2024，Vol.36Issue(4)：205-210,6.DOI:10.11952/j.issn.1007-1954.2024.04.003
射频消融与外科手术在富动脉血供肿块型肝内胆管癌中的疗效对比
Comparison of therapeutic effectiveness of radiofrequency ablation and surgical procedures in patients with intrahepatic mass-forming cholangiocarcinoma with rich arterial blood supply
摘要
Abstract
Objective Discussing the differences in treatment outcomes between radiofrequency ablation(RFA)and surgical procedures in patients with intrahepatic mass-forming cholangiocarcinoma(IMCC)with rich arterial blood supply.Methods A retrospective analysis was conducted on patients with IMCC confirmed by pathology and showing rich arterial blood supply on enhanced magnetic resonance imaging(MRI)scans at Central Hospital in Lishui City and the First Affiliated Hospital of Guangxi Medical University from Sep.2014 to Apr.2020.The patients were divided into the surgical group(24 cases)and the interventional group(13 cases)based on treatment methods.Clinical,pathological,and radiological data were compared between the two groups using t-tests and Mann-Whitney U tests.Kaplan-Meier analysis and Log-rank tests were used to analyze the intergroup survival rates.Results There was no statistical significant difference in preoperative general clinical data,laboratory test results,imaging findings of lesions,or postoperative tumor pathological differentiation between the two groups(all P>0.05).The total postoperative complications rate in the interventional group was significantly lower than that in the surgical group[38.5%(5/13)vs 91.7%(22/24),Z=-3.432,P=0.001].During the follow-up period ranging from 0.6 to 109.3 months,the surgical group had 7 deaths,17 survivors,and 12 recurrences,with an average survival time of 82.2 months.The overall survival(OS)rate was 70.8%,and the relapse-free survival(RFS)rate was 37.2%.The 1-,3-,and 5-year survival rates were 91.7%,79.2%,and 70.8%respectively,while the 1-,3-,and 5-year recurrence rates were 13.6%,40.9%,and 50.4%respectively.The intervention group had 4 deaths,9 survivors,and 7 recurrences,with an average survival time of 84.7 months.The OS was 67.3%,and the RFS was 44.9%.The 1-,3-,and 5-year survival rates were 100.0%,84.6%,and 67.3%respectively,while the 1-,3-,and 5-year recurrence rates were 15.4%,46.2%,and 55.1%respectively.No statistically significant difference was found in OS(χ2=0.002,P=0.969)and RFS(χ2=0.009,P=0.923)between the two groups.Conclusion RFA and traditional surgical procedures have comparable therapeutic effects in patients with IMCC with rich arterial blood supply.关键词
肝内胆管癌/富动脉血供/动脉增强/射频消融/手术/预后Key words
intrahepatic cholangiocarcinoma/rich arterial blood supply/arterial enhancement/radiofrequency ablation/surgery/prognosis分类
医药卫生引用本文复制引用
沈少博,彭帅,吴慧,张坤,李芳,李炳荣,纪建松..射频消融与外科手术在富动脉血供肿块型肝内胆管癌中的疗效对比[J].肝胆胰外科杂志,2024,36(4):205-210,6.基金项目
丽水市科技计划项目(2022GYX35,2023SJZC031). （2022GYX35,2023SJZC031）
