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The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis

Yutaro Ando Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu

国际口腔科学杂志（英文版）2024，Vol.16Issue(1)：154-162,9.

国际口腔科学杂志（英文版）2024，Vol.16Issue(1)：154-162,9.DOI:10.1038/s41368-023-00275-8

The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis

Yutaro Ando ¹Kazuo Okamoto ²Kenta Nakano ³Tadashi Okamura ³Akira Yamaguchi ⁴Kazuyuki Ishihara ⁵Hiroshi Takayanagi ⁶Masayuki Tsukasaki ²Nam Cong-Nhat Huynh ⁷Shizao Zang ⁶Minglu Yan ⁶Ryunosuke Muro ⁶Kazutaka Nakamura ⁸Masatsugu Komagamine ⁹Noriko Komatsu⁶

作者信息

1. Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan||Department of Microbiology,Tokyo Dental College,2-1-14 Kanda-Misaki-cho,Chiyoda-ku,Tokyo,Japan||Oral Health Science Center,Tokyo Dental College,Tokyo,Japan
2. Department of Osteoimmunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan
3. Department of Laboratory Animal Medicine,Research Institute,National Center for Global Health and Medicine,Tokyo,Japan
4. Oral Health Science Center,Tokyo Dental College,Tokyo,Japan
5. Department of Microbiology,Tokyo Dental College,2-1-14 Kanda-Misaki-cho,Chiyoda-ku,Tokyo,Japan||Oral Health Science Center,Tokyo Dental College,Tokyo,Japan
6. Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan
7. Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan||Unit of Prosthodontics,Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-Stomatology,University of Medicine and Pharmacy at Ho Chi Minh City,Ho Chi Minh City,Vietnam
8. Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan||Department of Oral and Maxillofacial Surgery,Department of Sensory and Motor System Medicine,Graduate School of Medicine,The University of Tokyo,Tokyo,Japan
9. Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan||Division of Rheumatology,Department of Internal Medicine,Keio University School of Medicine,Tokyo,Japan
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摘要

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Yutaro Ando,Kazuo Okamoto,Kenta Nakano,Tadashi Okamura,Akira Yamaguchi,Kazuyuki Ishihara,Hiroshi Takayanagi,Masayuki Tsukasaki,Nam Cong-Nhat Huynh,Shizao Zang,Minglu Yan,Ryunosuke Muro,Kazutaka Nakamura,Masatsugu Komagamine,Noriko Komatsu..The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis[J].国际口腔科学杂志（英文版）,2024,16(1):154-162,9.

基金项目

We thank S.Yin,K.Kusubata,A.Suematsu,K.Kubo,T.Tsubokawa,N.Takeda,and I.Komuro for thoughtful discussion and valuable technical assistance.This work was supported in part by the Japan Agency for Medical Research and Development(AMED)under grant number JP20ek0410073,JP23ek0410108,JP22ek0410100,AMED-CREST under grant number JP19gm1210008 and AMED-PRIME under grant number JP21gm6310029,the AMED Japan Initiative for World leading Vaccine Research and Development Centers(JP223fa627001) （AMED）

Japan Society for the Promotion of Science(JSPS):Scientific Research S(21H05046),Scientific Research B(21H03104,22H03195,and 22H02844)and Challenging Research(20K21515 and 21K18254) （JSPS）

and the JST FOREST Program(JPMJFR2261,JPMJFR205Z).Y.A.was supported by a JSPS Research Fellowship for Young Scientists(23KJ1949)and Japanese Society for Immunology(JSI)Kibou Scholarship for Doctoral Students in Immunology. （JPMJFR2261,JPMJFR205Z）

国际口腔科学杂志（英文版）

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