国际妇产科学杂志2024，Vol.51Issue(2)：128-132,5.DOI:10.12280/gjfckx.20230733
细菌性阴道病的治疗进展
Progress in Treatment of Bacterial Vaginosis
摘要
Abstract
Bacterial vaginosis(BV)is the most common lower reproductive tract infection among women of childbearing age,leading to an increasing risk of pelvic inflammatory disease,poor pregnancy outcomes,and multiple sexually transmitted infections.At present,the main clinical drugs used for BV treatment are antibiotics such as metronidazole and clindamycin,but it is difficult to solve the problems of treatment failure and high recurrence rate in some patients.The reason might be that the antibiotics have a single mechanism of bacterial inhibition,and the intensity is insufficient,which cannot rebuild the vaginal microbiota dominated by Lactobacillus,nor can they inhibit the production of pathogenic biofilms dominated by Gardnerella vaginalis.Therefore,there is an urgent need to develop new alternative drugs or combination therapies for BV treatment.This article reviews the recent research advances in new treatment for BV based on its microbiological foundation,especially lactobacillus preparations and biofilm inhibitors.Most of these therapies have good safety and high effectiveness,with great research value.Some of the applications have been available in clinic practice in these years.关键词
阴道病,细菌性/生物膜/治疗/下生殖道感染/阴道菌群Key words
Vaginosis,bacterial/Biofilms/Therapy/Lower reproductive tract infection/Vaginal flora引用本文复制引用
牛涵菲,韩钦..细菌性阴道病的治疗进展[J].国际妇产科学杂志,2024,51(2):128-132,5.基金项目
国家重点研发计划(2022YFB3604704) （2022YFB3604704）
