国际妇产科学杂志2024，Vol.51Issue(2)：133-136,4.DOI:10.12280/gjfckx.20230761
褪黑素与早发性卵巢功能不全关系的研究进展
The Relationship between Melatonin and Premature Ovarian Insufficiency
摘要
Abstract
Premature ovarian insufficiency(POI)is a clinical syndrome in women who develops ovarian insufficiency before the age of 40 years,which manifests itself as a weakening of reproductive and endocrine functions,and is one of the most important factors leading to female infertility,but the pathogenesis is unknown and the treatment is limited.Melatonin is a neuroendocrine hormone mainly synthesized and secreted by the pineal gland,which exerts effects in regulating circadian rhythms,antioxidant activity,and scavenging free radicals.Studies have shown that melatonin is involved in regulating ovarian steroid hormone synthesis,follicular development,ovulation and oocyte quality.Animal models for studies of POI have found that melatonin can alleviate oxidative stress,reduce apoptosis,regulate ovarian function and delay POI through the regulation of multiple signaling pathways.Clinical studies have shown that melatonin can improve ovarian function and pregnancy rate in POI patients.Its potential value in assisted reproduction provides a new direction to improve the fertility of POI patients.关键词
原发性卵巢功能不全/褪黑激素/抗氧化剂/不育,女(雌)性/生殖技术,辅助/氧化性应激Key words
Primary ovarian insufficiency/Melatonin/Antioxidant/Infertility,female/Reproductive techniques,assisted/Oxidative stress引用本文复制引用
寿梦娜,黄艺舟,周坚红..褪黑素与早发性卵巢功能不全关系的研究进展[J].国际妇产科学杂志,2024,51(2):133-136,4.基金项目
浙江省自然科学基金(LY22H040004) （LY22H040004）
浙江大学医学院附属妇产科医院"4+X"临床研究项目(ZDFY2022-4XA101) （ZDFY2022-4XA101）
