国际妇产科学杂志2024，Vol.51Issue(2)：215-219,5.DOI:10.12280/gjfckx.20231088
铜与卵巢癌的研究进展
Research Progress in Copper and Ovarian Cancer
邹乔剑 1姚书忠 1陈怡李 1刘军秀1
作者信息
- 1. 510000 广州,中山大学附属第一医院妇产科
- 折叠
摘要
Abstract
Ovarian cancer is one of the common gynecological malignant tumors,and most patients with ovarian cancer are discovered in their advanced stage,their prognosis and treatment effects are usually poor,which also seriously affects the quality of patients'survival.Copper is an important trace element that participates in various important biological processes in human body and correlates closely with the progression of many malignant tumors.An increasing number of studies have explored the relationship between copper and ovarian cancer.Previous research has noticed that copper levels are apparently higher in the plasma,ascites,and tumor tissue of ovarian cancer patients than in healthy women,and the abnormal expressions of a variety of copper-transporting proteins is closely related to the resistance to platinum-based drug chemotherapy in ovarian cancer.Recently,anti-tumor therapy targeting copper metabolism has become a hot research topic.Many studies have demonstrated the significant inhibitory effect of copper chelators and ionophores on ovarian cancer in vitro and in vivo.To summarizes the close relationship between copper and ovarian cancer,and to gain a deeper understanding of the application of copper-metabolism-based drugs and therapies,which may provide new insight into the treatment of ovarian cancer.关键词
卵巢肿瘤/铜/铜离子转运蛋白类/铜转移三磷酸酶类/抗肿瘤联合化疗方案/顺铂Key words
Ovarian neoplasms/Copper/Copper transport proteins/Copper-transporting ATPases/Antineoplastic combined chemotherapy protocols/Cisplatin引用本文复制引用
邹乔剑,姚书忠,陈怡李,刘军秀..铜与卵巢癌的研究进展[J].国际妇产科学杂志,2024,51(2):215-219,5.
