国际妇产科学杂志2024，Vol.51Issue(2)：232-235,4.DOI:10.12280/gjfckx.20230702
原发性DICER1相关宫颈横纹肌肉瘤一例
A Case Report of Primary DICER1 Associated Cervical Rhabdomyosarcoma
张明君 1黄爱华 2高亮2
作者信息
- 1. 116044 大连医科大学研究生院||南京医科大学附属泰州人民医院妇产科
- 2. 南京医科大学附属泰州人民医院妇产科
- 折叠
摘要
Abstract
Rhabdomyosarcoma has a highly malignancy and rare.A 17-year-old patient who was admitted to the hospital for 2 years due to incomplete menstrual bleeding was reported,after perfecting the pelvic magnetic resonance imaging which revealed cervical and vaginal masses.Our hospital performed cervical biopsy,and rapid pathological examination revealed malignant tumors.Later,a walking radical surgery was performed in an external hospital.Postoperative pathology and molecular testing showed that it was DICER1-associated embryonal rhabdomyosarcoma.After surgery,we combined radiotherapy and chemotherapy.Follow up until August 2023 showed no clinical or imaging recurrence,and tumor markers were normal.The clinical symptoms of embryonal rhabdomyosarcoma of the female reproductive tract are atypical,and its occurrence is closely related to the mutation of DICERi gene.Individualized treatment plans should be developed based on the patient's age,tumor location,and fertility protection needs,and follow-up monitoring should be strengthened.关键词
宫颈肿瘤/横纹肌肉瘤/癌,胚胎性/核糖核酸酶Ⅲ/基因/突变Key words
Uterine cervical neoplasms/Rhabdomyosarcoma/Carcinoma,embryonal/Ribonuclease Ⅲ/Genes/Mutation引用本文复制引用
张明君,黄爱华,高亮..原发性DICER1相关宫颈横纹肌肉瘤一例[J].国际妇产科学杂志,2024,51(2):232-235,4.
