中国妇幼健康研究2024，Vol.35Issue(4)：25-31,7.DOI:10.3969/j.issn.1673-5293.2024.04.004
早期干预对NICU早产儿体格及神经心理发育的效果研究
Effects of early intervention on physical and neuropsychological development in NICU preterm infants
摘要
Abstract
Objective To investigate the effects of early intervention on the physical and neuropsychological development of preterm infants in neonatal intensive care unit(NICU)within two years.Methods A total of 102 NICU preterm infants treated at Suzhou Municipal Hospital from January 2018 to December 2020 were selected as the intervention group,and 105 healthy full-term infants born during the same period were randomly selected as the control group.Results At 24 months of age,the Z-scores for weight,length and head circumference of low-risk preterm infants who received early intervention reached level similar to full-term infants(0.34±0.98,0.40±1.30 and 0.54±1.04,respectively,P＞0.05),however,the Z-scores for these measures in the high-risk preterm infants were lower compared to the full-term group(-0.17±1.15,0.00±1.29,and-0.33±1.24,respectively,P＜0.05).In terms of gross motor development,by 6 to 24 months corrected age,both high-risk and low-risk preterm infants reached levels comparable to full-term infants.At 24 months of age,the mean scores for high-risk,low-risk and full-term infants were 101.81±10.05,102.06± 10.85,and 100.47±9.40,respectively(all P＞0.05).In terms of language and social behavior,by 18 to 24 months corrected age,the development level of preterm infants could reach the level of full-term infants.In terms of adaptive development,before 18 months corrected age,the adaptive ability of high-risk and low-risk preterm infants could reach full-term infants,however,at 24 months,the adaptive ability of preterm infants were lower than that of full-term infants,and the adaptive ability of high-risk infants,low-risk infants and full-term infants were 102.77±12.04,101.73±10.34,106.78±9.31,respectively(all P＜0.05).Similar trends were observed for fine motor development,at 12 months corrected age,the fine motor level of high-risk and low-risk preterm infants could reach full-term infants,and at 18 to 24 months corrected age,the fine motor level of high-risk and low-risk preterm infants were lower than full-term infants.Conclusion Within the first two years after birth,there are differences in physical and neuropsychological development between high-risk and low-risk preterm infants,with high-risk preterm infants exhibiting more pronounced delays.Understanding the physical and neuropsychological development of premature infants correctly and formulating individualized early intervention mode play a crucial role in physical and neuropsychological development of premature infants.关键词
早产儿/体格发育/神经心理发育/早期干预Key words
preterm infants/physical development/neuropsychological development/early intervention分类
医药卫生引用本文复制引用
孔锐,陆晓婷,宋媛,叶侃,戴月娥..早期干预对NICU早产儿体格及神经心理发育的效果研究[J].中国妇幼健康研究,2024,35(4):25-31,7.基金项目
中国疾病预防控制中心妇幼保健中心2019年度"母婴营养与健康研究项目"(2019FYH026) （2019FYH026）
