神经损伤与功能重建2024，Vol.19Issue(4)：211-216,6.DOI:10.16780/j.cnki.sjssgncj.20221114
老年轻型急性缺血性卒中患者非HDL-C/HDL-C比值与1年卒中复发的关系研究
Research on the Relationship between Non-HDL-C/HDL-C Ratio and One-Year Stroke Re-currence in Elderly Patients with Mild Acute Ischemic Stroke
摘要
Abstract
Objective:To investigate the relationship between the ratio of non-high-density lipoprotein choles-terol(non-HDL-C)to high-density lipoprotein cholesterol(HDL-C)and the risk of one-year stroke recurrence in elderly patients with mild acute ischemic stroke(AIS).Methods:Through the Xi'an Stroke Registry Research database,we continuously collected patients'total cholesterol,HDL-C,and related clinical information at the time of admission,as well as follow-up data on recurrent stroke events at 3,6,and 12 months after diagnosis.Non-HDL-C was calculated by subtracting HDL-C from total cholesterol.The non-HDL-C/HDL-C ratio was an-alyzed both as a continuous variable and as quartile groups(Q1～Q4).Multivariate Cox regression analysis was used to explore the relationship between the non-HDL-C/HDL-C ratio and the risk of one-year stroke recurrence in elderly patients with mild AIS.The Kaplan-Meier method was employed to analyze one-year stroke recur-rence for different non-HDL-C/HDL-C ratios.Results:A total of 826 elderly patients with mild AIS were in-cluded in the study.After adjusting for relevant confounding factors,multivariate Cox regression analysis re-vealed that for each unit increase in the non-HDL-C/HDL-C ratio,the risk of one-year stroke recurrence in-creased by 54％(HR=1.54,95％CI 1.15～2.07,P=0.004).Compared to the Q1 group,the risk of one-year stroke recurrence was 2.27 times higher in the Q4 group(HR=3.27,95％CI 1.21～8.81,P=0.019),while there was no statistically significant difference in the risk of one-year stroke recurrence between other groups(Q2 and Q3)and Q1.The trend test showed a significant statistical increase in one-year recurrence risk from Q1 to Q4 groups(trend test P=0.004).Curve fitting analysis indicated that as the non-HDL-C/HDL-C ratio increased,the risk of one-year stroke recurrence gradually rose.K-M survival analysis of the quartiles found that compared to other groups,the one-year stroke recurrence rate was significantly higher in the Q4 group(≥3.58).Conclusion:An elevated non-HDL-C/HDL-C ratio is probably an independent risk factor for one-year stroke recurrence in elder-ly patient with mild AIS,and a ratio ≥ 3.58 significantly increases the risk of one-year stroke recurrence in these patients.关键词
急性缺血性卒中/老年/非传统/血脂/复发Key words
acute ischemic stroke/elderly/non-traditional/serum lipid/recurrence分类
临床医学引用本文复制引用
王欢,刘仲仲,蔺雪梅,张娜,逯青丽,刘佩,常乔乔,刘燕,吴松笛..老年轻型急性缺血性卒中患者非HDL-C/HDL-C比值与1年卒中复发的关系研究[J].神经损伤与功能重建,2024,19(4):211-216,6.基金项目
陕西省科技计划项目(超重和肥胖脑卒中患者血清残余胆固醇水平对入院严重程度及其预后的影响,No.2023-YBSF-041) （超重和肥胖脑卒中患者血清残余胆固醇水平对入院严重程度及其预后的影响,No.2023-YBSF-041）
西安市科技计划项目(残余胆固醇水平与超重和肥胖卒中患者入院严重程度及其预后的相关研究,No.22YXYJ0061 （）
急性视交叉后部视觉通路脑卒中患者视网膜特征评估,No.22YXYJ0074) （）
西安市卫生健康委员会科研项目(Non-HDL-c/HDL-c比值对非致残性缺血性卒中患者预后的预测价值研究,No.2021yb33) （Non-HDL-c/HDL-c比值对非致残性缺血性卒中患者预后的预测价值研究,No.2021yb33）
