神经损伤与功能重建2024，Vol.19Issue(4)：封4-封4,1.DOI:10.16780/j.cnki.sjssgncj.202404015
腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关
Adenosine Receptors are the On-and-off Switch of Astrocytic Cannabinoid Type 1(CB1)Receptor Effect upon Synaptic Plasticity in the Medial Prefrontal Cortex
Joana Gonçalves-Ribeiro 1Gemma Navarro 2Rafael Franco 3Sandra H Vaz 1Oksana K Savchak 1Sara Costa-Pinto 1Joana I Gomes 1Rafael Rivas-Santisteban 4Alejandro Lillo 4Javier Sánchez Romero 5Ana M Sebastião 1Marta Navarrete6
作者信息
- 1. Instituto de Farmacologia e Neurociências,Faculdade de Medicina,Universidade de Lisboa,Lisbon,Portugal||Instituto de Medicina Molecular João Lobo Antunes,Faculdade de Medicina,Universidade de Lisboa,Lisbon,Portugal
- 2. Department of Biochemistry and Physiology,School of Pharmacy and Food Science,Universitat de Barcelona,Barcelona,Spain||CiberNed,Network Center for Neurodegenerative Diseases,National Spanish Health Institute Carlos Ⅲ,Madrid,Spain||Institut de Neurociències,Universitat de Barcelona,Barcelona,Spain
- 3. CiberNed,Network Center for Neurodegenerative Diseases,National Spanish Health Institute Carlos Ⅲ,Madrid,Spain||Molecular Neurobiology Laboratory,Department of Biochemistry and Molecular Biomedicine,Faculty of Biology,Universitat de Barcelona,Barcelona,Spain||School of Chemistry,Universitat de Barcelona,Barcelona,Spain
- 4. Department of Biochemistry and Physiology,School of Pharmacy and Food Science,Universitat de Barcelona,Barcelona,Spain||CiberNed,Network Center for Neurodegenerative Diseases,National Spanish Health Institute Carlos Ⅲ,Madrid,Spain
- 5. Instituto Cajal,CSIC,Madrid,Spain||PhD Program in Neuroscience,Universidad Autónoma de Madrid-Instituto Cajal,Madrid,Spain
- 6. Instituto Cajal,CSIC,Madrid,Spain
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摘要
Abstract
The medial prefrontal cortex(mPFC)is involved in cognitive functions such as working memory.Astrocytic canna-binoid type 1 receptor(CB1R)induces cytosolic calcium(Ca2+)concentration changes with an impact on neuronal function.mPFC astrocytes also express adenosine A1 and A2A receptors(A1 R,A2A R),being unknown the crosstalk between CB1R and adenosine receptors in these cells.We show here that a further level of regulation of astrocyte Ca2+signaling occurs through CB1R-A2A R or CB1R-A1 R heteromers that ultimately impact mPFC synaptic plasticity.CB1R-mediated Ca2+transients in-creased and decreased when A1 R and A2A R were activated,respectively,unveiling adenosine receptors as modulators of astro-cytic CB1R.CB1R activation leads to an enhancement of long-term potentiation(LTP)in the mPFC,under the control of A,R but not of A2A R.Notably,in IP3R2KO mice,that do not show astrocytic Ca2+ level elevations,CB1R activation decreases LTP,which is not modified by A,R or A2A R.The present work suggests that CB1R has a homeostatic role on mPFC LTP,under the control of A1 R,probably due to physical crosstalk between these receptors in astrocytes that ultimately alters CB1R Ca2+sig-naling.关键词
CB1受体/腺苷受体/星形胶质细胞/内侧前额叶皮质/突触可塑性Key words
CB1 receptor/adenosine receptors/astroglia/mPFC/synaptic plasticity分类
医药卫生引用本文复制引用
Joana Gonçalves-Ribeiro,Gemma Navarro,Rafael Franco,Sandra H Vaz,Oksana K Savchak,Sara Costa-Pinto,Joana I Gomes,Rafael Rivas-Santisteban,Alejandro Lillo,Javier Sánchez Romero,Ana M Sebastião,Marta Navarrete..腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关[J].神经损伤与功能重建,2024,19(4):封4-封4,1.
