广西医学2024，Vol.46Issue(1)：10-14,5.DOI:10.11675/j.issn.0253-4304.2024.01.02
肠道菌群及耐药基因组与抗生素之间关系的研究进展
Relation of intestinal flora and drug resistance genome with antibiotics:a research progress
摘要
Abstract
Genes carried by intestinal flora are considered as"the second genome"of humans,and intestinal flora is also reservoir of antibiotic resistance gene(ARG).Disturbance in composition and function of intestinal flora is related to multiple diseases.However,the use of antibiotics disrupts the original homeostasis of intestinal flora,intensifies spread and diffusion of ARG,increases abundance of specific ARG,and exerts adverse effects on clinical treatment.In this review,the relation of intestinal flora and drug resistance genome with antibiotics is summarized,and future research directions are prospected,aiming at providing new ideas for the research of intestinal drug resistance genome and theoretical basis for the rational use of antibiotics in clinics at the same time.关键词
肠道菌群/肠道耐药基因组/抗生素耐药基因/抗生素/综述Key words
Intestinal flora/Intestinal drug resistance genome/Antibiotic resistance gene/Antibiotics/Review分类
医药卫生引用本文复制引用
叶闻瑜,冯彩霞,单庆文..肠道菌群及耐药基因组与抗生素之间关系的研究进展[J].广西医学,2024,46(1):10-14,5.基金项目
国家自然科学基金(82060101) （82060101）
广西儿科疾病临床医学研究中心(桂科AD22035219) （桂科AD22035219）
