广西医学2024，Vol.46Issue(1)：20-25,6.DOI:10.11675/j.issn.0253-4304.2024.01.04
孤独症谱系障碍与肠道菌群的相关性的研究进展
Correlation of autism spectrum disorder with intestinal flora:a research progress
摘要
Abstract
Autism spectrum disorder(ASD)is diseases of neurodevelopmental disorder with high genetic heterogeneity.Except for neurological symptoms,a lot of ASD children usually exhibit concomitant gastrointestinal symptoms.Increasing evidences indicate that the composition of intestinal flora in ASD children changes significantly,and abnormal intestinal flora may be involved in the occurrence and development of ASD through the microbe-intestine-brain axis.At present,there is no effective drug to ameliorate the core symptoms of ASD.In this review,the potential relation of intestinal microecological flora and its metabolites with ASD,and microecotherapy such as probiotics,prebiotics,and fecal microbiota transplantation in the application values of ASD are summarized,aiming at providing more references for ameliorating the core symptoms of ASD children.关键词
孤独症谱系障碍/肠道菌群/代谢产物/微生物-肠-脑轴/微生态疗法/综述Key words
Autism spectrum disorder/Intestinal flora/Metabolites/Microbe-intestine-brain axis/Microecotherapy/Review分类
医药卫生引用本文复制引用
李杏,龙开贤,黄诗琴,袁海,韩蕴丽..孤独症谱系障碍与肠道菌群的相关性的研究进展[J].广西医学,2024,46(1):20-25,6.基金项目
广西医科大学第一附属医院临床研究攀登计划青年科技启明星计划项目(YYZS2020019) （YYZS2020019）
