肠道菌群在儿童支气管哮喘发病机制中的研究进展OACSTPCD

Bronchial asthma(hereinafter referred to as asthma)is a chronic respiratory disease with a high incidence rate worldwide.In recent years,the incidence rate of asthma in children has increased significantly.The pathogenesis of asthma is extremely complex,and it is not entirely clear.Studies have revealed that there is a significant difference in the composition structure of intestinal flora between asthma and healthy population,and intestinal flora may be involved in the occurrence and development of asthma through regulating T lymphocyte subsets,dendritic cells,airway epithelial cells,mucosal immune,related signaling pathways,and other approaches,whereas its metabolites such as short chain fatty acids,lipopolysaccharide,tryptophan,secondary bile acids may exert dual regulation effects of protection or promotion in the onset of asthma.In this review,research progress on intestinal flora and its metabolites in the pathogenesis of asthma in children is summarized.