广州化学2024，Vol.49Issue(2)：16-23,8.DOI:10.16560/j.cnki.gzhx.20240215
孕烯醇酮D环结构修饰的合成方法及生物活性研究进展
Progress in Synthetic Methods and Biological Activities of Pregnenolone D-ring Structural Modifications
摘要
Abstract
The structure of steroids and their wide range of applications in medicine are briefly described.Firstly,it is elaborated that 16-dehydropregnenolone acetate(16-DPA)occupies an important position in steroid synthesis as a key intermediate in the synthesis of steroid drugs.Subsequently,the synthetic methods of modifying the D-ring of 16-DPA with different groups to obtain steroid derivatives are reviewed in detail,including N-heterocyclic(oxazole,pyrazole,pyrimidine,and imidazole),O-heterocyclic,carbocyclic,and other modifications.As well as their displayed biological activities such as anti-tumor and anti-inflammatory are analyzed.Finally,it is summarized and its development trend and application prospects are outlooked.关键词
16-DPA/孕烯醇酮/位点修饰/甾体/抗肿瘤活性Key words
16-DPA/pregnenolone/site modification/steroid/anti-tumor activity分类
化学化工引用本文复制引用
董远,马养民,马思悦..孕烯醇酮D环结构修饰的合成方法及生物活性研究进展[J].广州化学,2024,49(2):16-23,8.基金项目
国家自然科学基金(No.22178205) （No.22178205）
陕西省重点研发计划(2022GY-203) （2022GY-203）
中国博士后基金(2022M711994) （2022M711994）
