哈尔滨商业大学学报（自然科学版）2024，Vol.40Issue(2)：131-138,8.
草苁蓉抗衰老作用的网络药理学研究
Network pharmacological study on anti-aging effect of Boschniakia rossica
摘要
Abstract
Through network pharmacology and molecular docking to explore the active ingredients,key targets,and potential molecular mechanisms of Boschniakia rossica in anti-aging,and to provide a basis for the development of Boschniakia rossica in anti-aging.Using TCMSP and HERB databases to obtain the active ingredients and targets of Boschniakia rossica;using OMIM,GeneCards,and DisGeNET databases to obtain aging related targets;using the Venny 2.1.0 platform to obtain intersection targets;using STRING platform and Cytoscape 3.9.1 software to create PPI network;using DAVID database and bioinformatics online platform to conduct GO and KEGG analysis on intersecting targets;software such as Openbabel,Autodock,PyMOL,and platforms such as PLIP for was used for molecular docking verification and visualization processing.Thirty active ingredients from Boschniakia rossica,436 component targets,1814 age-relate targets,and 215 intersection targets from component and disease were selected.GO and KEGG analyses found that the anti-aging effect of Boschniakia rossica involved multiple biological processes such as negative feedback on cell apoptosis and response to drugs.The intersection targets were mainly concentrated in 20 core pathways such as cancer,PI3K-AKT signaling and MAPK signaling.Molecular docking results showed that oleanolic acid,3-epioleanolic acid and boschnaloside from Boschniakia rossica exhibited good binding potential with key targets of GAPDH,AKT1 and IL6.Boschniakia rossica acts on the key targets of GAPDH,AKT1 and IL6 through oleanolic acid,3-epioleanolic acid and boschnaloside.They participated in PI3K-Akt signaling pathway,MAPK signaling pathway,HIF-1 signaling pathway and other pathways.To exert RNA polymerase II transcription factor activity,apoptosis negative feedback and drug reaction to plays the role of anti-aging.关键词
草苁蓉/抗衰老/网络药理学/分子对接/作用机制Key words
Boschniakia rossica/anti-aging/network pharmacology/molecular docking/mechanism of action分类
医药卫生引用本文复制引用
杨雪晶,杨辉萍,张天雷..草苁蓉抗衰老作用的网络药理学研究[J].哈尔滨商业大学学报（自然科学版）,2024,40(2):131-138,8.基金项目
黑龙江省中医药管理局中医药科研课题项目(ZHY2022-045) （ZHY2022-045）
黑龙江省中医药经典普及化专项课题项目(ZYW2022-064) （ZYW2022-064）
