哈尔滨商业大学学报（自然科学版）2024，Vol.40Issue(2)：147-156,10.
火麻仁多肽泡腾片的制备工艺优化
Optimization of preparation process of hemp seed polypeptide effervescent tablets
陶悦 1王孜硕 2张坤 2熊志伟 2梁伟2
作者信息
- 1. 哈尔滨商业大学 药学院,哈尔滨 150076
- 2. 哈尔滨商业大学 药学院,哈尔滨 150076||黑龙江省预防与治疗老年病药物研究重点实验室,哈尔滨 150076
- 折叠
摘要
Abstract
This paper explored the optimal preparation process and quality standard evaluation of hemp seed peptide effervescent tablets through single factor analysis and response interviews.Using a comprehensive score as an indicator,examine the proportion and amount of excipients added,and use response surface methodology to design the optimal solution.Through screening,the optimal plan was to add 4.58%lubricant,43.35%disintegrant,1.2∶1 disintegrant ratio,and 1.82%flavor correction agent.And quality standard evaluation and preliminary stability investigation were conducted on the peptide effervescent tablets of hemp seed.The appearance,hardness,disintegration time limit,pH value,fragility,microbial limit of the peptide effervescent tablets were used as detection indicators.The results indicated that they all complied with the relevant provisions of the Chinese Pharmacopoeia and have good stability.This paper conducted a systematic study on hemp seed peptides through single factor and response interviews,providing theoretical reference and guidance for the preparation of hemp seed peptide effervescent tablets.关键词
火麻仁/多肽/泡腾片/响应面/综合评分/工艺优化Key words
hemp seed/peptides/effervescent tablet/response surface/comprehensive rating/process optimization分类
医药卫生引用本文复制引用
陶悦,王孜硕,张坤,熊志伟,梁伟..火麻仁多肽泡腾片的制备工艺优化[J].哈尔滨商业大学学报（自然科学版）,2024,40(2):147-156,10.
