基础医学与临床2024，Vol.44Issue(5)：606-612,7.DOI:10.16352/j.issn.1001-6325.2024.05.0606
血尿素氮水平对急性冠状动脉综合征患者PCI术后MACE的预测价值
Value of blood urea nitrogen level in prediction of MACE after PCI in patients with acute coronary syndrome
摘要
Abstract
Objective To explore the relationship and predictive function of blood urea nitrogen(BUN)level in association with major adverse cardiovascular event(MACE)subsequent to percutaneous coronary intervention(PCI)among patients diagnosed with acute coronary syndrome(ACS).Methods Between April 2017 and November 2017,ACS patients undergoing their initial PCI at the Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University were recruited.Following a 36-month follow-up period,487 patients were in-cluded as 114 subjects experiencing MACE and 373 subjects without MACE.The Cox proportional hazards regres-sion model was utilized to assess the risk ratio of MACE and its 95％confidence interval(CI)concerning BUN lev-els and ACS post-PCI.Additionally,the area under the receiver operating characteristic(ROC)curve(AUC)was applied to assess the predictive effect of BUN.Results After adjusting for confounding variables,Cox proportional hazards regression analysis revealed that the risk of MACE was approximately four times higher in the high BUN lev-el group compared to the low BUN level group(OR=4.722,95％CI 1.716-12.993).Upon inclusion of BUN in both the basic prediction model and SCORE model for cardiovascular event risk,there was a significant increase in the AUC area(P＜0.001).Conclusions BUN levels can independently predict the risk of MACE following PCI in ACS patients,irrespective of traditional risk factors.关键词
急性冠状动脉综合征/主要不良心血管事件(MACE)/血尿素氮/经皮冠状动脉介入治疗(PCI)Key words
acute coronary syndrome/major adverse cardiovascular event(MACE)/blood urea nitrogen/percutaneous coronary in-tervention(PCI)分类
医药卫生引用本文复制引用
高晓倩,于华惠,刘圣,焦晓璐,吕倩雯,张铭,秦彦文..血尿素氮水平对急性冠状动脉综合征患者PCI术后MACE的预测价值[J].基础医学与临床,2024,44(5):606-612,7.基金项目
国家重点研发计划(2021YFC2500600,2021YFC2500603) （2021YFC2500600,2021YFC2500603）
北京市医学科研院所公益性发展和改革试点项目(JYY2021-7) （JYY2021-7）
